N^a-fluorenylmethyloxycarbonyl-N⁵-(5'-deoxy-5'-cytidyl(N⁴-benzoyl))-L-isoglutamine | 623166-66-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: N^a-fluorenylmethyloxycarbonyl-N⁵-(5'-deoxy-5'-cytidyl(N⁴-benzoyl))-L-isoglutamine
• 英文别名: (4S)-5-[[(2R,3S,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid
• CAS: 623166-66-5
• 化学式: C₃₆H₃₅N₅O₁₀
• 分子量: 697.701
• InChiKey: OAUAHMKRTONQNW-LHEQKTAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  51
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  216
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N⁵-(N⁴-benzoyl-5'-deoxy-5'-cytidyl)-L-isoglutamine benzyl ester trifluoroacetic acid salt 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.17h， 生成 N^a-fluorenylmethyloxycarbonyl-N⁵-(5'-deoxy-5'-cytidyl(N⁴-benzoyl))-L-isoglutamine
  参考文献：
  名称：

  Solid-phase synthesis of peptide ribonucleic acids (PRNA)

  摘要：

  The range of available peptide ribonucleic acid (PRNA) monomers was fully expanded for the use in solid-phase synthesis of PRNA oligomers, which were designed to reversibly control the recognition and complexation behavior of the complementary DNA/RNA by external factors. A couple of PRNA 12-mers with desired purine-pyrimidine mixed sequences were prepared indeed in high yields by the solid-phase synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.08.024

文献信息

• Solid-phase synthesis of peptide ribonucleic acids (PRNA)
  作者：Hirofumi Sato、Yusuke Hashimoto、Takehiko Wada、Yoshihisa Inoue

  DOI：10.1016/j.tet.2003.08.024

  日期：2003.9

  The range of available peptide ribonucleic acid (PRNA) monomers was fully expanded for the use in solid-phase synthesis of PRNA oligomers, which were designed to reversibly control the recognition and complexation behavior of the complementary DNA/RNA by external factors. A couple of PRNA 12-mers with desired purine-pyrimidine mixed sequences were prepared indeed in high yields by the solid-phase synthesis. (C) 2003 Elsevier Ltd. All rights reserved.