1-Amino-naphthalin-sulfonamid-4 | 5695-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Amino-naphthalin-sulfonamid-4
• 英文别名: 4-amino-naphthalene-1-sulfonic acid amide；4-Amino-naphthalin-1-sulfonsaeure-amid；4-Amino-naphthalinsulfonamid-(1)；Naphthionamid；Naphthionsaeure-amid；4-Aminonaphthalene-1-sulfonamide
• CAS: 5695-34-1
• 化学式: C₁₀H₁₀N₂O₂S
• 分子量: 222.268
• InChiKey: RNFQLWOXVAPWPR-UHFFFAOYSA-N

物化性质

• 熔点：
  212 °C
• 沸点：
  490.2±47.0 °C(Predicted)
• 密度：
  1.435±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Amino-naphthalin-sulfonamid-4 生成 4-(4-amino-naphthalene-1-sulfonylamino)-naphthalene-1-sulfonic acid amide
  参考文献：
  名称：

  Hiyama, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 1370,1373

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Acetylaminonaphthalinsulfonamid-4 在 盐酸 作用下， 生成 1-Amino-naphthalin-sulfonamid-4
  参考文献：
  名称：

  Goldyrew; Postowskii, 1938, vol. 11, p. 316,318, 319

  摘要：

  DOI：

文献信息

• SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY
  申请人：Northwestern University

  公开号：US20170001976A1

  公开（公告）日：2017-01-05

  Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

  公开了具有取代喹唑啉核心结构的新小分子，以及它们用于调节葡萄糖苷脂酶活性的用途。还公开了包含这些小分子或与小分子结合的激活葡萄糖苷脂酶的药物组合物，这些组合物可以用于治疗与葡萄糖苷脂酶活性相关的疾病或失调，包括神经系统疾病和失调，如戈谢病和帕金森病。
• FLUORESCENT ANTICANCER PLATINUM DRUGS
  申请人：INVICTUS ONCOLOGY PVT. LTD.

  公开号：US20180312534A1

  公开（公告）日：2018-11-01

  The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

  本公开涉及纳米技术和癌症治疗领域。具体而言，本公开涉及荧光铂基化合物。该公开进一步涉及合成所述荧光铂基化合物、纳米颗粒和包含所述荧光铂基化合物/纳米颗粒的组合物。该公开还涉及通过上述铂基化合物与相应的游离配体、纳米颗粒和组合物之间的荧光变化来管理癌症的方法。
• [EN] SUBSTITUTED 4-METHYL-PYRROLO[1.2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY<br/>[FR] COMPOSÉS DE 4-MÉTHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE SUBSTITUÉ ET LEURS UTILISATIONS POUR MODULER L'ACTIVITÉ DE LA GLUCOCÉRÉBROSIDASE
  申请人：UNIV NORTHWESTERN

  公开号：WO2017004408A1

  公开（公告）日：2017-01-05

  Disclosed are new small molecules having a 4-methylpyrrrolo[l,2-a]pyrimidine- 8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.

  揭示了具有4-甲基吡咯并[1,2-a]嘧啶-8-羧酰胺核结构的新型小分子及其用途，用于调节葡萄糖乙酰硫脂酶活性。还揭示了包含这些小分子的药物组合物，可用于治疗与葡萄糖乙酰硫脂酶活性相关的疾病或疾病，包括神经系统疾病和障碍，如高雪氏病和帕金森病。这些小分子可能含有荧光团或与荧光团结合，以制备用于高通量筛选方法中的荧光探针，以通过荧光极化识别葡萄糖乙酰硫脂酶活性的新调节剂。
• COMPOUNDS HAVING PHOTOCHEMICALLY REMOVABLE PROTECTING GROUPS BASED ON AN ELECTROCYCLIC REACTION BETWEEN A CHROMOPHORE ATTACHED VIA AN ANILIDE GROUP TO A BENZOTHIOPHENE RING
  申请人：MARQUETTE UNIVERSITY

  公开号：US20130231484A1

  公开（公告）日：2013-09-05

  Disclosed herein are compounds having photoremovable protecting groups which are removed after the compounds absorbs light of a given wavelength and undergo an electrocyclic reaction between a chromophore in the compound attached via an anilide to a benzothiophene ring.

  本文披露了一种化合物，其具有光可去保护基团，该基团在化合物吸收特定波长的光并在连接到苯并噻吩环的苯胺上的染料团之间发生电环反应后被去除。
• MONITORING AND ASSESSING DEACETYLASE ENZYME ACTIVITY
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20160138077A1

  公开（公告）日：2016-05-19

  Disclosed herein are compounds and methods for detecting enzyme activity. In some embodiments, the enzyme is a deacetylase enzyme such as HDAC. The compound of the invention comprises a detectable label, a linker, and an enamide group. The compound can be enzymatically cleaved by the enzyme of interest to produce a nucleophilic fragment that includes the detectable label. Measurement of a signal generated by the detectable label can indicate enzyme activity. The compounds can be used as either in vivo or in vitro enzyme probes.

  本文披露了一种检测酶活性的化合物和方法。在某些实施例中，该酶是去乙酰化酶，如HDAC。该发明的化合物包括可检测的标记、连接剂和烯酰胺基团。该化合物可以被感兴趣的酶酶切割，产生包含可检测标记的亲核片段。通过测量可检测标记产生的信号可以指示酶活性。这些化合物可以用作体内或体外酶探针。