N-[4-fluoro-1-(1H-pyrrol-2-ylcarbonyl)piperidin-4-yl]methyl-N-(5-methylpyridin-2-yl)methylamine | 1149762-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[4-fluoro-1-(1H-pyrrol-2-ylcarbonyl)piperidin-4-yl]methyl-N-(5-methylpyridin-2-yl)methylamine
• 英文别名: [4-fluoro-4-[[(5-methylpyridin-2-ylmethyl)amino]methyl]piperidin-1-yl]-pyrrol-2-yl-methanone；[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]-(1H-pyrrol-2-yl)methanone
• CAS: 1149762-07-1
• 化学式: C₁₈H₂₃FN₄O
• 分子量: 330.405
• InChiKey: FQSZWNGFQAGGND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  61
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-fluoropiperidin-4-yl)methyl-N-(5-methylpyridin-2-yl)methylamine trihydrochloride 、 吡咯-2-羧酸 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 以31%的产率得到N-[4-fluoro-1-(1H-pyrrol-2-ylcarbonyl)piperidin-4-yl]methyl-N-(5-methylpyridin-2-yl)methylamine
  参考文献：
  名称：

  Novel Pyridylmethylamines as Highly Selective 5-HT_1A Superagonists

  摘要：

  To further improve the maximal serotonergic efficacy and better understand the configurational requirements for 5-HT1A binding and activation, we generated and biologically investigated structural variants of the lead structure befiradol. For a bioisosteric replacement of the 3-chloro-4-fluoro moiety, a focused library of 63 compounds by solution phase parallel synthesis was developed. Target binding of our compound collection was investigated, and their affinities for 5-HT2, alpha(1), and alpha(2)-adrenergic as well as D-1-D-4 at dopamine receptors were compared. For particularly interesting test compounds, intrinsic activities at 5-HT1A were examined in vitro employing a GTP gamma S assay. The investigation guided as to highly selective 5HT(1A) superagonists. The benzothiophene-3-carboxamide 8bt revealed almost exclusive 5HT(1A) recognition with a K-i value of 2.7 nM and a maximal efficacy of 124%. To get insights into the bioactive conformation of our compound collection, we synthesized conformationally constrained bicyclic scaffolds when SAR data indicated a chair-type geometry and an equatorially dispositioned aminomethyl substituent for the 4,4-disubstituted piperidine moiety.

  DOI：

  10.1021/jm100835q

文献信息

• Heteroaryl-substituted 2-pyridinyl-methylamine derivatives
  申请人：SCHWARZ PHARMA AG

  公开号：EP2058306A1

  公开（公告）日：2009-05-13

  The present disclosure relates to compounds having the general formula I wherein Q represents a five membered heteroaryl group. The compounds are selective 5-HT1a modulators and are useful for treating several diseases.

  本公开涉及具有通式 I 的化合物 其中 Q 代表五元杂芳基。这些化合物是选择性 5-HT1a 调节剂，可用于治疗多种疾病。
• Novel Pyridylmethylamines as Highly Selective 5-HT_1A Superagonists
  作者：Stefan Bollinger、Harald Hübner、Frank W. Heinemann、Karsten Meyer、Peter Gmeiner

  DOI：10.1021/jm100835q

  日期：2010.10.14

  To further improve the maximal serotonergic efficacy and better understand the configurational requirements for 5-HT1A binding and activation, we generated and biologically investigated structural variants of the lead structure befiradol. For a bioisosteric replacement of the 3-chloro-4-fluoro moiety, a focused library of 63 compounds by solution phase parallel synthesis was developed. Target binding of our compound collection was investigated, and their affinities for 5-HT2, alpha(1), and alpha(2)-adrenergic as well as D-1-D-4 at dopamine receptors were compared. For particularly interesting test compounds, intrinsic activities at 5-HT1A were examined in vitro employing a GTP gamma S assay. The investigation guided as to highly selective 5HT(1A) superagonists. The benzothiophene-3-carboxamide 8bt revealed almost exclusive 5HT(1A) recognition with a K-i value of 2.7 nM and a maximal efficacy of 124%. To get insights into the bioactive conformation of our compound collection, we synthesized conformationally constrained bicyclic scaffolds when SAR data indicated a chair-type geometry and an equatorially dispositioned aminomethyl substituent for the 4,4-disubstituted piperidine moiety.