piperidine-1-carboxylic acid 2-formylphenyl ester | 1548303-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: piperidine-1-carboxylic acid 2-formylphenyl ester
• 英文别名: (2-Formylphenyl) piperidine-1-carboxylate；(2-formylphenyl) piperidine-1-carboxylate
• CAS: 1548303-16-7
• 化学式: C₁₃H₁₅NO₃
• 分子量: 233.267
• InChiKey: WGNDMKPIKYIHSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶-1-甲醛 、 水杨醛 在 叔丁基过氧化氢 、 copper(l) chloride 作用下， 反应 1.5h， 以88%的产率得到piperidine-1-carboxylic acid 2-formylphenyl ester
  参考文献：
  名称：

  Copper-Catalyzed Oxidative Coupling of Formamides with Salicylaldehydes: Synthesis of Carbamates in the Presence of a Sensitive Aldehyde Group

  摘要：

  A diverse library of novel carbamates was synthesized utilizing copper-catalyzed oxidative C-O coupling of formamides and salicylaldehydes. Sensitive aldehyde groups remained intact in the presence of an oxidant and a transition-metal salt. Salicylaldehydes bearing electron-donating, electron-withdrawing, and halogen groups as well as 1-hydroxy-2-naphthaldehydes provided the desired carbamates in good to excellent yields.

  DOI：

  10.1021/jo402798k

文献信息

• Quinoline-2-carboimine copper complex immobilized on amine functionalized silica coated magnetite nanoparticles: a novel and magnetically retrievable catalyst for the synthesis of carbamates via C–H activation of formamides
  作者：R. K. Sharma、Sriparna Dutta、Shivani Sharma

  DOI：10.1039/c4dt03236e

  日期：——

  In the present study, we report the synthesis of a highly efficient and magnetically retrievable catalytic system (Cu-2QC@Am-SiO2@Fe3O4) through the covalent immobilization of quinoline-2-carboxaldehyde (2QC) on an amine functionalized silica coated ferrite nanosupport followed by metallation with copper acetate. The structure of the organic–inorganic hybrid nanomaterial has been confirmed using various

  在本研究中，我们报告了一种高效且可磁回收的催化体系（Cu-2QC @ Am-SiO 2 @Fe 3 O 4）的合成）通过将喹啉-2-甲醛（2QC）共价固定在胺官能化的二氧化硅包覆的铁氧体纳米载体上，然后用乙酸铜金属化。有机-无机杂化纳米材料的结构已通过各种物理化学技术得到了证实，例如粉末X射线衍射（XRD），傅立叶变换红外光谱（FT-IR），扫描电子显微镜（SEM），透射电子显微镜（TEM） ，能量色散X射线光谱法（EDS），能量色散X射线荧光光谱法（ED-XRF），原子吸收光谱法（AAS），电感耦合等离子体光谱法（ICP）和振动样品磁强法（VSM）。所得的纳米催化剂在工业和药学上重要的氨基甲酸酯的合成中显示出显着的催化功效。在无溶剂条件下通过C–H活化甲酰胺。本方法的最重要的属性是催化剂可以简单地通过外部磁力来回收并重复使用几次而其活性没有任何显着降低。此外，为了确保纳米结构催化剂的固有
• BCL-2 INHIBITORS
  申请人：BeiGene, Ltd.

  公开号：EP3788042A1

  公开（公告）日：2021-03-10
• Copper-Catalyzed Oxidative Coupling of Formamides with Salicylaldehydes: Synthesis of Carbamates in the Presence of a Sensitive Aldehyde Group
  作者：Balaji D. Barve、Yang-Chang Wu、Mohamed El-Shazly、Da-Wei Chuang、Yuan-Bin Cheng、Jeh-Jeng Wang、Fang-Rong Chang

  DOI：10.1021/jo402798k

  日期：2014.4.4

  A diverse library of novel carbamates was synthesized utilizing copper-catalyzed oxidative C-O coupling of formamides and salicylaldehydes. Sensitive aldehyde groups remained intact in the presence of an oxidant and a transition-metal salt. Salicylaldehydes bearing electron-donating, electron-withdrawing, and halogen groups as well as 1-hydroxy-2-naphthaldehydes provided the desired carbamates in good to excellent yields.