2,5-Bis(4-guanidino-2,6-dimethylphenyl)furan | 423165-16-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-Bis(4-guanidino-2,6-dimethylphenyl)furan
• 英文别名: Guanidine, N,Na(2)a(2)a(2)-[2,5-furandiylbis(3,5-dimethyl-4,1-phenylene)]bis-；2-[4-[5-[4-(diaminomethylideneamino)-2,6-dimethylphenyl]furan-2-yl]-3,5-dimethylphenyl]guanidine
• CAS: 423165-16-6
• 化学式: C₂₂H₂₆N₆O
• 分子量: 390.488
• InChiKey: WNCYRFZZXOZFCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
  申请人：——

  公开号：US20020156098A1

  公开（公告）日：2002-10-24

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula 1 wherein Y is a heteroatom; R 1 and R 2 are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X 1 , X 2 , and X 3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, acylamino, alkylthio, sulfonyl, cyano, carboxy, alkoxycarbonyl, or carbamoyl group are disclosed.

  本发明涉及用于治疗、预防或抑制利什曼病的方法，包括向受试者施用至少一种具有结构式1的化合物的治疗有效量，其中Y是杂原子；R1和R2分别是H或烷基、环烷基、杂环烷基、芳基、氨基或杂芳基基团；X1、X2和X3分别是H或烷基、烷氧基、卤素、氨基、烷基氨基、二烷基氨基、酰胺基、烷硫基、磺酰基、氰基、羧基、烷氧羰基或氨基甲酰基基团。
• US6706754B2
  申请人：——

  公开号：US6706754B2

  公开（公告）日：2004-03-16
• [EN] REVERSED AMIDINES AND METHODS OF USING FOR TREATING, PREVENTING, OR INHIBITING LEISHMANIASIS<br/>[FR] AMIDINES INVERSEES ET METHODES D'UTILISATION POUR TRAITER, PREVENIR, ET INHIBER LA LEISHMANIOSE
  申请人：US ARMY MED RES MAT COMMAND

  公开号：WO2002036588A2

  公开（公告）日：2002-05-10

  Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula (I) wherein Y is a heteroatom; R?1 and R2¿ are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X1, X2, and X¿3? are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino acylamino, alkylthio, sulfonyl, cyano, carboxy alkoxycarbonyl, or carbamoyl group are disclosed.