2-(2-nitrophenyl)-3-phenylacrylonitrile | 19051-30-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(2-nitrophenyl)-3-phenylacrylonitrile
• 英文别名: 2-(2-Nitrophenyl)-3-phenylprop-2-enenitrile
• CAS: 19051-30-0
• 化学式: C₁₅H₁₀N₂O₂
• 分子量: 250.257
• InChiKey: QPOKESDOJWYPOO-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C(Solv: ethanol (64-17-5))
• 沸点：
  413.4±40.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(2-硝基-苯基)-5-苯基-二氢-呋喃-2,3-二酮 在 sodium hydroxide 、 盐酸羟胺 作用下， 生成 2-(2-nitrophenyl)-3-phenylacrylonitrile
  参考文献：
  名称：

  催化硼氢化钠对邻硝基苯基丙酮酸甲酯和其他酮酸酯的某些衍生物进行还原环化

  摘要：

  3-氨基-1-羟基喹啉-2（1 H）-一（Va）是硼氢化钠和钯-木炭还原邻硝基苯基丙酮酸甲酯的肟时的产物之一。声称相同的喹诺酮是邻硝基硝基丙酮酸乙酯肟的催化氢化产物之一，这一说法被证明是错误的。描述了用硼氢化钠和钯-木炭还原肟基，亚苄基和所选酮酯的其他衍生物。

  DOI：

  10.1039/j39690002207

文献信息

• Ammonium Chloride: An Efficient and Environmentally benign Catalyst for Knoevenagel Condensation of Carbonyl and Active Methylene Compounds
  作者：S. Tasqeeruddin、Yahya I. Asiri、M. Mujahid A lam

  DOI：10.14233/ajchem.2020.22879

  日期：——

  In the present study, a rapid, simple and an efficient procedure for the Knoevenagel condensation of various carbonyl and active methylene compounds in ethanol at a moderate temperature in the presence of a catalytic amount of an efficient, environmentally benign and inexpensive ammonium chloride is reported. Simple reaction procedure, economic and ecofriendly catalyst, mild reaction conditions and

  在本研究中，报道了一种快速、简单且有效的方法，用于在催化量的高效、环境友好且廉价的氯化铵存在下，在中等温度下在乙醇中对各种羰基和活性亚甲基化合物进行Knoevenagel缩合。反应流程简单、催化剂经济环保、反应条件温和、产品收率良好至优异是本研究的特点。非萃取后处理/纯化、经济且环境友好的催化剂使得这种操作简单的程序适合大规模使用。
• A Simple and Highly Versatile Procedure for the Knoevenagel Condensation Promoted by an Efficient, Eco-Friendly, and Recyclable nano-ZnO Catalyst
  作者：S. Tasqeeruddin、Ya. I. Asiri、M. M. Alam、S. Sh. Sulthana

  DOI：10.1134/s1070428020020220

  日期：2020.2

  A simple, highly versatile, and efficient protocol for the synthesis of substituted olefins from various aromatic aldehydes and active methylene compounds by Knoevenagel condensation using an efficient, eco-friendly, and recyclable nano-ZnO catalyst in ethanol at a moderate temperature was developed. Due to its large surface area, the nano-ZnO catalyst exhibited an excellent catalytic activity. The advantages of the method included milder conditions, short reaction times, and easy work-up and purification of products by non-chromatographic methods. The catalysts can be recovered for subsequent reactions and reused without any appreciable loss of efficiency.
• Reductive cyclisation of some derivatives of methyl o-nitrophenyl-pyruvate and other keto-esters by catalysed sodium borohydride
  作者：R. T. Coutts、Gita Mukherjee、R. A. Abramovitch、M. A. Brewster

  DOI：10.1039/j39690002207

  日期：——

  ne (Va) is one of the products when the oxime of methyl o-nitrophenyl-pyruvate is reduced with sodium borohydride and palladium–charcoal. The claim that the same quinolone is one of the products of the catalytic hydrogenation of ethyl o-nitrophenylpyruvate oxime is shown to be erroneous. Reduction of the oximino-, benzylidene, and other derivatives of selected keto-esters with sodium borohydride and

  3-氨基-1-羟基喹啉-2（1 H）-一（Va）是硼氢化钠和钯-木炭还原邻硝基苯基丙酮酸甲酯的肟时的产物之一。声称相同的喹诺酮是邻硝基硝基丙酮酸乙酯肟的催化氢化产物之一，这一说法被证明是错误的。描述了用硼氢化钠和钯-木炭还原肟基，亚苄基和所选酮酯的其他衍生物。