N-o-Tolyl-2-aminonaphthalin-6-sulfonsaeure | 34322-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-o-Tolyl-2-aminonaphthalin-6-sulfonsaeure
• 英文别名: 6-o-toluidino-naphthalene-2-sulfonic acid；N-o-Tolyl-naphthylamin-(2)-sulfonsaeure-(6)；6-o-Toluidino-naphthalin-2-sulfonsaeure；2-Naphthalenesulfonic acid, 6-[(methylphenyl)amino]-；6-(2-methylanilino)naphthalene-2-sulfonic acid
• CAS: 34322-41-3
• 化学式: C₁₇H₁₅NO₃S
• 分子量: 313.377
• InChiKey: ZNCYFNAQLNQTDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium 2-naphthol-6-sulfonate 、 邻甲苯胺 在 sodium disulfite 作用下， 生成 N-o-Tolyl-2-aminonaphthalin-6-sulfonsaeure
  参考文献：
  名称：

  Bucherer; Stohmann, Journal fur praktische Chemie (Leipzig 1954), 1905, vol. <2> 71, p. 435,449

  摘要：

  DOI：

文献信息

• Nucleic acid labeling compounds
  申请人：McGall H. Glenn

  公开号：US20050003496A1

  公开（公告）日：2005-01-06

  Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. Methods for making such heterocyclic compounds are also disclosed. The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.

  揭示了含有杂环衍生物的核酸标记化合物。还公开了制备这种杂环化合物的方法。这些标记化合物适用于通过酶的附着，无论是末端还是内部，提供核酸检测的机制。
• REAGENTS FOR LABELLING NUCLEIC ACIDS AND USES THEREOF
  申请人：Mouritzen Peter

  公开号：US20090023594A1

  公开（公告）日：2009-01-22

  The present invention relates to labelling kits containing novel non-natural nucleotide monomers and to methods of making and using such compounds. The invention further relates to a method of detecting the presence of a nucleic acid, e.g., RNA, of interest in a sample, the method having the following steps: providing the sample; ligating a nucleic acid of interest with a labelling reagent according to the instant invention; providing a nucleic acid array having probes directed to the nucleic acid of interest; hybridizing the labelled nucleic acid fragments to said nucleic acid array; and determining the extent of hybridization to said probes to determine the presence of the nucleic acid of interest.

  本发明涉及包含新型非自然核苷酸单体的标记试剂盒以及制备和使用这些化合物的方法。本发明还涉及一种检测样品中感兴趣的核酸（例如RNA）存在的方法，该方法包括以下步骤：提供样品；使用本发明的标记试剂将感兴趣的核酸连接起来；提供具有针对感兴趣的核酸的探针的核酸阵列；将标记的核酸片段杂交到该核酸阵列上；并确定杂交到探针的程度以确定感兴趣的核酸是否存在。
• NUCLEIC ACID LABELING COMPOUNDS
  申请人：——

  公开号：US20010018514A1

  公开（公告）日：2001-08-30

  Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.

  本发明揭示了含有杂环衍生物的核酸标记化合物。这些含有杂环衍生物的化合物是通过将杂环衍生物与环状基团（例如核糖呋喃衍生物）缩合而合成的。这些标记化合物适用于酶促连接到核酸上，无论是末端或内部，以提供核酸检测的机制。
• HIGH THROUGHPUT METHOD FOR FUNCTIONALLY CLASSIFYING PROTEINS IDENTIFIED USING A GENOMICS APPROACH
  申请人：——

  公开号：US20010003648A1

  公开（公告）日：2001-06-14

  The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.

  本发明提供了一种用于功能分类能够由于热变化而展开的蛋白质的方法。该方法包括筛选多种不同分子中的一种或多种，以确定它们改变蛋白质的热展开曲线的能力，其中热展开曲线的变化表示该分子结合到蛋白质上或以可测量的方式影响其稳定性；生成蛋白质的活性谱，其中活性谱反映了多种分子中的一组分子，这些分子改变了蛋白质的热展开曲线，因此它们是结合到蛋白质上的配体；将蛋白质的活性谱与一个或多个功能参考谱列表进行比较；并根据多种不同分子中改变蛋白质的热展开曲线的分子组合将蛋白质进行分类。
• High throughput method for functionally classifying proteins identified using a genomics approach
  申请人：——

  公开号：US20020168686A1

  公开（公告）日：2002-11-14

  The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.

  本发明提供了一种功能分类能够由于热变化而发生展开的蛋白质的方法。该方法包括筛选一种或多种不同分子的多重组合，以检测它们移动蛋白质的热展开曲线的能力，其中热展开曲线的移动表示该分子结合到蛋白质或以可测量的方式影响其稳定性；生成蛋白质的活性谱，其中活性谱反映了从多重分子中移动蛋白质的热展开曲线的分子集，因此是结合到蛋白质的配体；将蛋白质的活性谱与一个或多个功能参考谱列表进行比较；并根据多种不同分子的集合将蛋白质进行分类，这些分子移动蛋白质的热展开曲线。