Benzoic acid, 3,3'-carbonylbis[6-[(1-naphthalenylcarbonyl)amino]- | 755040-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Benzoic acid, 3,3'-carbonylbis[6-[(1-naphthalenylcarbonyl)amino]-
• 英文别名: 5-[3-carboxy-4-(naphthalene-1-carbonylamino)benzoyl]-2-(naphthalene-1-carbonylamino)benzoic acid
• CAS: 755040-95-0
• 化学式: C₃₇H₂₄N₂O₇
• 分子量: 608.6
• InChiKey: BKDUCWKFFJGDAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  46
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
  申请人：Shapiro Robert

  公开号：US20070032418A1

  公开（公告）日：2007-02-08

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• US7264932B2
  申请人：——

  公开号：US7264932B2

  公开（公告）日：2007-09-04