N-(piperidinomethyl)-urea | 5657-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(piperidinomethyl)-urea
• 英文别名: N-piperidinomethylurea；piperidinomethyl urea；piperidinomethylurea；PMU；Piperidinylmethylureido；piperidin-1-ylmethylurea
• CAS: 5657-34-1
• 化学式: C₇H₁₅N₃O
• 分子量: 157.216
• InChiKey: COCPIUNVTGEHQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(piperidinomethyl)-urea 、 nickel dibromide 以 N,N-二甲基甲酰胺 、 正丁醇 为溶剂， 生成 NiBr2(piperidinomethylurea)2
  参考文献：
  名称：

  Sabastiyan; Venkappayya, Journal of the Indian Chemical Society, 1990, vol. 67, # 7, p. 584 - 585

  摘要：

  DOI：

文献信息

• [EN] FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES FUSIONNÉS ET LEUR UTILISATION
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009136663A1

  公开（公告）日：2009-11-12

  The present invention provides a fused heterocyclic derivative having a strong kinase inhibitory activity and use thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

  本发明提供了一种具有强烈激酶抑制活性的融合杂环衍生物及其用途。本发明涉及本说明书中所定义的符号表示的化合物，或其盐。
• FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF
  申请人：Miyamoto Naoki

  公开号：US20110046169A1

  公开（公告）日：2011-02-24

  The present invention provides a fused heterocyclic derivative having a strong kinase inhibitory activity and use thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

  本发明提供了一种具有强大的激酶抑制活性的熔合杂环衍生物及其使用。本发明涉及一种由式子所表示的化合物，其中每个符号如本说明书中所定义的，或其盐。
• FUSED HETEROCYCLE DERIVATIVES AND USE THEREOF
  申请人：OGURO Yuya

  公开号：US20090163488A1

  公开（公告）日：2009-06-25

  A compound represented by the formula (I): wherein Z 1 , Z 2 , Z 3 and Z 4 are the following combination, (Z 1 ,Z 2 ,Z 3 ,Z 4 )=(CR 4 ,N,CR 5 ,C), (N,N,CR 5 ,C), (N,C,CR 5 ,N), (S,C,CR 5 ,C) or (S,C,N,C); R 1 and R 2 are the same or different and each is (1) a hydrogen atom, (2) a halogen atom, (3) a group bonded via a carbon atom, (4) a group bonded via a nitrogen atom, (5) a group bonded via an oxygen atom or (6) a group bonded via a sulfur atom; R 3 is an amino optionally having substituent(s); R 4 and R 5 are the same or different and each is (1) a hydrogen atom, (2) a halogen atom, (3) a group bonded via a carbon atom, (4) a group bonded via a nitrogen atom, (5) a group bonded via an oxygen atom or (6) a group bonded via a sulfur atom; R 3 and R 4 optionally form a ring optionally having substituent(s); and a group represented by the formula is a cyclic group optionally having substituent(s), or a salt thereof.

  化合物的分子式为（I）：其中Z1，Z2，Z3和Z4是以下组合，（Z1，Z2，Z3，Z4）=（CR4，N，CR5，C），（N，N，CR5，C），（N，C，CR5，N），（S，C，CR5，C）或（S，C，N，C）; R1和R2相同或不同，每个都是（1）氢原子，（2）卤原子，（3）通过碳原子键合的基团，（4）通过氮原子键合的基团，（5）通过氧原子键合的基团或（6）通过硫原子键合的基团; R3是氨基，可以有取代基; R4和R5相同或不同，每个都是（1）氢原子，（2）卤原子，（3）通过碳原子键合的基团，（4）通过氮原子键合的基团，（5）通过氧原子键合的基团或（6）通过硫原子键合的基团; R3和R4可以选择形成一个环，也可以有取代基; 以及由公式表示的基团是一个环状基团，可以有取代基，或其盐。
• Anand, Sarika, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2007, vol. 46, # 3, p. 401 - 406
  作者：Anand, Sarika

  DOI：——

  日期：——
• Synthesis and characterization of cyano complexes of oxotungsten(IV) with morpholinomethyl urea and related ligands
  作者：M. S. Pathania、H. N. Sheikh、B. L. Kalsotra

  DOI：10.1134/s0036023606090075

  日期：2006.9

  The synthesis and characterization of complexes, (Ph3P)(2)NH2[WO(CN)(3)L-L] center dot 3H(2)O and Cs[WO(CN)(3)L-L] center dot H2O (where L-L = morpholinomethylurea, morpholinomethylthiourea, piperidinomethylurea, piperidinomethylthiourea, pyrrolidinomethylurea, and pyrrolidinomethythiourea) are presented. The complexes have been prepared by the reaction of K3Na[WO2(CN)(4)] center dot 6H(2)O with morpholinomethylurea and related ligands in aqueous solution around a pH of 7. These have been isolated as bis(triphenylphospine)imminium or cesium salts. The complexes have been characterized by elemental analysis, IR, UV-Vis spectra, magnetic susceptibility and conductivity measurements in addition to TGA/DTA.