6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxyaldehyde | 79424-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxyaldehyde
• 英文别名: 6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxaldehyde；(6-ethoxycarbonyloxy-3-formyl-4-oxochromen-7-yl) ethyl carbonate
• CAS: 79424-54-7
• 化学式: C₁₆H₁₄O₉
• 分子量: 350.282
• InChiKey: RNTHDYYLVKCOCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxyaldehyde 生成 6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxylic acid
  参考文献：
  名称：

  NOMOTO, SEIICHIRO;IKUTA, HIRONORI;MACHIDA, YOSHIMASA;NEGI, SHIGETO;SUGIYA+

  摘要：

  DOI：
• 作为产物：
  描述：

  4,5-Bis(ethoxycarbonyloxy)-2-hydroxyacetophenone 生成 6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxyaldehyde
  参考文献：
  名称：

  NOMOTO, SEIICHIRO;IKUTA, HIRONORI;MACHIDA, YOSHIMASA;NEGI, SHIGETO;SUGIYA+

  摘要：

  DOI：

文献信息

• 7.alpha.-Methoxycephalosporin derivatives, and antibacterial drugs
  申请人：Eisai Co., Ltd.

  公开号：US04415567A1

  公开（公告）日：1983-11-15

  Novel 7.alpha.-methoxycephalosporin derivatives, their pharmaceutically acceptable salts, process for the preparation thereof, and antibacterial drugs involving the derivative or salt. The derivatives or salts are effective against the Gram-positive bacteria and the Gram-negative bacteria.

  小说7.alpha.-甲氧基头孢菌素衍生物，其药用盐，其制备方法，以及涉及该衍生物或盐的抗菌药物。这些衍生物或盐对革兰氏阳性菌和革兰氏阴性菌有效。
• Chromone derivatives
  申请人：Eisai Co., Ltd.

  公开号：US04309354A1

  公开（公告）日：1982-01-05

  New chromone derivatives having the formula: ##STR1## wherein A represents a hydrogen atom, a halogen atom or a hydroxyl group, and R.sub.1 represents a lower alkyl or a chloro-substituted lower alkyl group. The derivatives are useful intermediates for synthesis of cephem derivatives as antibacterial drugs.

  新的色酮衍生物具有以下公式：##STR1## 其中A代表氢原子，卤素原子或羟基，R.sub.1代表低碳基或氯代低碳基。这些衍生物是合成头孢菌素衍生物作为抗菌药物的有用中间体。
• 7-.alpha.-methoxycephalosporin derivatives, and antibacterial drugs
  申请人：Eisai Co., Ltd.

  公开号：US04344944A1

  公开（公告）日：1982-08-17

  Novel 7.alpha.-methoxycephalosporin derivatives, their pharmaceutically acceptable salts, process for the preparation thereof, and antibacterial drugs involving the derivative or salt. The derivatives or salts are effective against the Gram-positive bacteria and the Gram-negative bacteria.

  小说7.alpha.-甲氧基头孢菌素衍生物，其药用盐，其制备过程，以及包含该衍生物或盐的抗菌药物。该衍生物或盐对革兰氏阳性菌和革兰氏阴性菌均有效。
• Cephem derivatives and antibacterial agents comprising said compounds
  申请人：Eisai Co., Ltd.

  公开号：US04352801A1

  公开（公告）日：1982-10-05

  Cephem derivatives represented by the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, R.sub.2 represents a lower alkyl group or a chloro-substituted lower alkyl group, and R.sub.3 represents a lower alkanoyloxy group or a nitrogen-containing heterocyclic thio group, and the pharmaceutically acceptable salts thereof. The cephem derivatives exhibit excellent antibacterial activity and are effective against Gram-positive and Gram-negative bacteria.

  Cephem衍生物的化学式为：##STR1## 其中R.sub.1代表氢原子或羟基，R.sub.2代表低碳基或氯代低碳基，R.sub.3代表低烷酰氧基或含氮杂环硫基，以及其药学上可接受的盐。这些Cephem衍生物表现出极佳的抗菌活性，对革兰氏阳性和革兰氏阴性菌均有效。
• Cephem derivatives, process for producing thereof, and antibacterial agents comprising said compounds
  申请人：Eisai Co., Ltd.

  公开号：EP0049309A1

  公开（公告）日：1982-04-14

  Cephem derivatives represented by the formula: wherein R1 represents a hydrogen atom or a hydroxyl group, R2 represents a lower alkyl group or a chloro-substituted lower alkyl group, and R3 represents a lower alkanoyloxy group or a nitrogen-containing heterocyclic thio group, and the pharmaceutically acceptable salts thereof. The cephem derivatives exhibit excellent antibacterial activity and are effective against Gram-positive and Gram-negative bacteria.

  式中 R1 代表氢原子或羟基，R2 代表低级烷基或氯代低级烷基，R3 代表低级烷酰氧基或含氮杂环硫基的 Cephem 衍生物及其药学上可接受的盐类。 Cephem 衍生物具有优异的抗菌活性，对革兰氏阳性菌和革兰氏阴性菌均有效。