3-(4-sulfamoylphenyl)-4-(2',4'-dichlorophenyl)-2(5H)-furanone | 569362-75-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-(4-sulfamoylphenyl)-4-(2',4'-dichlorophenyl)-2(5H)-furanone
• 英文别名: 4-[3-(2,4-dichlorophenyl)-5-oxo-2H-furan-4-yl]benzenesulfonamide
• CAS: 569362-75-0
• 化学式: C₁₆H₁₁Cl₂NO₄S
• 分子量: 384.24
• InChiKey: BQTQJYZQMCTIBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  628.6±65.0 °C(Predicted)
• 密度：
  1.557±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  94.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(氨基磺酰基)苯乙酸 、 2-溴-2',4'-二氯苯乙酮 以30%的产率得到3-(4-sulfamoylphenyl)-4-(2',4'-dichlorophenyl)-2(5H)-furanone
  参考文献：
  名称：

  Compounds and methods for inducing apoptosis in proliferating cells

  摘要：

  用于诱导增殖细胞凋亡的化合物，特别是癌细胞，包括但不限于前列腺癌、白血病、非小细胞肺癌、结肠癌、中枢神经系统癌、黑色素瘤、卵巢癌、肾癌、膀胱癌、淋巴瘤和乳腺癌。这些化合物在治疗雄激素非依赖性癌症特别有效，包括激素难治性前列腺癌。还提供了使用本发明化合物治疗患有癌症的受试者的方法。此外，还提供了使用本发明化合物治疗、抑制或延迟受试者癌症发生的方法。此外，还提供了使用本发明化合物诱导快速增殖细胞凋亡的方法，特别是虽然不一定是癌细胞。

  公开号：

  US20030236294A1

文献信息

• COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS
  申请人：THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

  公开号：EP1499597A2

  公开（公告）日：2005-01-26
• EP1499597A4
  申请人：——

  公开号：EP1499597A4

  公开（公告）日：2006-01-25
• US7026346B2
  申请人：——

  公开号：US7026346B2

  公开（公告）日：2006-04-11
• [EN] COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS<br/>[FR] COMPOSES ET METHODES PERMETTANT D'INDUIRE L'APOPTOSE CHEZ DES CELLULES DE PROLIFERATION
  申请人：UNIV OHIO STATE RES FOUND

  公开号：WO2003086287A2

  公开（公告）日：2003-10-23

  Compounds useful for inducing apoptosis in proliferate cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.
• Compounds and methods for inducing apoptosis in proliferating cells
  申请人：——

  公开号：US20030236294A1

  公开（公告）日：2003-12-25

  Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-smalll cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.

  用于诱导增殖细胞凋亡的化合物，特别是癌细胞，包括但不限于前列腺癌、白血病、非小细胞肺癌、结肠癌、中枢神经系统癌、黑色素瘤、卵巢癌、肾癌、膀胱癌、淋巴瘤和乳腺癌。这些化合物在治疗雄激素非依赖性癌症特别有效，包括激素难治性前列腺癌。还提供了使用本发明化合物治疗患有癌症的受试者的方法。此外，还提供了使用本发明化合物治疗、抑制或延迟受试者癌症发生的方法。此外，还提供了使用本发明化合物诱导快速增殖细胞凋亡的方法，特别是虽然不一定是癌细胞。