3,4,5,6-四氯酚酞 | 639-44-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 3,4,5,6-四氯酚酞
• 英文名称: phenol-4,5,6,7-tetrachlorophthalein
• 英文别名: 4,5,6,7-tetrachloro-3,3-bis-(4-hydroxy-phenyl)-phthalide；4,5,6,7-Tetrachlor-3,3-bis-(4-hydroxy-phenyl)-phthalid；4.5.6.7-Tetrachlor-phenolphthalein；Phenoltetrachlorophthalein；4,5,6,7-tetrachloro-3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
• CAS: 639-44-1
• 化学式: C₂₀H₁₀Cl₄O₄
• 分子量: 456.109
• InChiKey: NPARLLRHBQQQDY-UHFFFAOYSA-N

物化性质

• 沸点：
  690.7±55.0 °C(Predicted)
• 密度：
  1.643±0.06 g/cm3(Predicted)
• 熔点：
  >300 °C

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  3,4,5,6-四氯酚酞 在 乙醇 、 溴 、 溶剂黄146 作用下， 生成 4,5,6,7-tetrachloro-3,3-bis-(3,5-dibromo-4-hydroxy-phenyl)-phthalide
  参考文献：
  名称：

  Orndorff; Black, American Chemical Journal, 1909, vol. 41, p. 377

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4,5,6-四氯-1,2-苯二甲酸半水合物 在 硫酸 作用下， 生成 3,4,5,6-四氯酚酞
  参考文献：
  名称：

  Orndorff; Black, American Chemical Journal, 1909, vol. 41, p. 360,366

  摘要：

  DOI：

文献信息

• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0046270A1

  公开（公告）日：1982-02-24

  Novel transient prodrug forms of bio-affecting phenolic compounds are selected from the group consisting of those having the structural formula (I): wherein X is O, S or NR5 wherein R5 is hydrogen or lower alkyl; R1 is the mono- or polydehydroxylated residue of a non-steroidal bio-affecting phenol, with the proviso that R' is other than a monohydroxylated or didehydroxylated residue of a phenolic, nuclear dihydroxy natural sympathetic or sympathomimetic amine; R2 is selected from the group consisting of straight or branched chain alkyl, aryl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aralkyl, alkaryl, aralkenyl, aralkynyl, alkenylaryl, alkynylaryl, (lower acyloxy)alkyl, and carboxyalkyl; 3- to 8-membered, saturated or unsaturated mono-heterocyclic or polyheterocyclic containing from 1 to 3 of any one or more of the heteroatoms N, S or O; and mono- or polysubstituted derivatives of the above; R3 is hydrogen, lower acyl, cyano, halo(lower alkyl), carbamyl, lower alkylcarbamyl, di(lower alkyl)carbamyl, CH2ONO2, -CH2OCOR2 or any non-heterocyclic member of the group defined by R2 above; and n is at least one and equals the total number of phenolic hydroxyl functions comprising the non-steroidal bioaffecting phenol etherified via a R2COXCH(R3)0-moiety; those having the structural formula (II): wherein X, R', R2 and R3 are as defined above, and n and m are each at least one and the sum of n+m equals the total number of phenolic hydroxyl functions comprising the non-steroidal bioaffecting phenol either etherified via a R2COXCH(R3)0-moiety or esterified via a R2COO-moiety; and the pharmaceutically acceptable acid addition salts, quaternary ammonium salts and N-oxides thereof.

  生物效应酚类化合物的新型瞬效原药形式选自具有结构式(I)的化合物组成的组： 其中 X 是 O、S 或 NR5，其中 R5 是氢或低级烷基；R1 是非类固醇生物效应酚的单羟基或多羟基残基，但 R' 不是酚、核二羟基天然交感胺或拟交感胺的单羟基或双羟基残基；R2 选自直链或支链烷基、芳基、环烷基、烯基、环烯基、炔基、芳烷基、烷芳基、芳烯基、芳炔基、烯芳基、炔芳基、（低级酰氧基）烷基和羧基烷基组成的组；R3 是氢、低级酰基、氰基、卤代（低级烷基）、氨甲酰基、低级烷基氨甲酰 基、二（低级烷基）氨甲酰基、CH2ONO2、-CH2OCOR2 或上述 R2 定义的基团中的任何非杂环成员；且 n 至少为 1，等于通过 R2COXCH(R3)0 子代醚化的非甾体生物作用酚所包含的酚羟基官能团的总数；具有结构式（II）的酚羟基官能团： 其中 X、R'、R2 和 R3 如上文所定义，n 和 m 至少各为 1，且 n+m 之和等于非甾体类生物效应酚通过 R2COXCH(R3)0 子键醚化或通过 R2COO 子键酯化的酚羟基官能团的总数；及其药学上可接受的酸加成盐、季铵盐和 N-氧化物。
• Noncrystallizable sensitized layers for OLED and OEDs
  申请人：MOLECULAR GLASSES, INC.

  公开号：US10211409B2

  公开（公告）日：2019-02-19

  Various embodiments of the present invention provide for a light emitting devices comprising a light emitting layer comprising an electroluminescent organic material dispersed in a matrix, wherein the electroluminescent organic material has a molecular weight less than about 2000 amu, the matrix comprises a nonelectroluminescent-nonpolymeric amorphous glass mixture, and each of the nonelectroluminescent-nonpolymeric organic molecular glass mixture and the electroluminescent organic material constitutes at least 20 percent by weight of the light emitting layer; and electrodes in electrical communication with the light emitting layer and configured to conduct an electric charge through the light emitting layer such that the light emitting layer emits light.

  本发明的各种实施例提供了一种发光器件，该器件包括一个发光层，该发光层包括分散在基质中的电致发光有机材料，其中电致发光有机材料的分子量小于约2000amu，基质包括非电致发光-非聚合非晶态玻璃混合物，且非电致发光-非聚合有机分子玻璃混合物和电致发光有机材料各自占发光层重量的至少20%；与发光层电气连接的电极，其配置可通过发光层传导电荷，从而使发光层发光。
• Indicator device
  申请人：INSIGNIA TECHNOLOGIES LIMITED

  公开号：US11371974B2

  公开（公告）日：2022-06-28

  There is described an indicator device comprising: an indicator section comprising an indicator material that displays different visible properties in response to the presence or absence of an activating agent; an activator section comprising an activating agent that effects a change in the visible properties of the indicator material; and a barrier section comprising a barrier layer that is substantially impermeable to the activating agent, the barrier section being located between the indicator section and the activator section; wherein at least part of the barrier layer is configurable to allow the activating agent and the indicator material to come into contact with each other, thereby effecting a visible change. The device may be used to detect or report the passage of time and can be applied to perishable goods and/or associated packaging to show that packaging has been compromised and/or that the device has been compromised.

  描述了一种指示器装置，该装置包括：指示器部分，由指示器材料组成，该指示器材料可随活化剂的存在或不存在而显示不同的可见特性；活化剂部分，由活化剂组成，该活化剂可使指示器材料的可见特性发生变化；以及阻隔层部分，由阻隔层组成，该阻隔层基本上不渗透活化剂，阻隔层位于指示器部分和活化剂部分之间；其中至少部分阻隔层可配置为允许活化剂和指示器材料相互接触，从而产生可见变化。该装置可用于检测或报告时间的流逝，并可应用于易腐货物和/或相关包装，以显示包装已损坏和/或装置已损坏。
• Orndorff; Kennedy, Journal of the American Chemical Society, 1916, vol. 38, p. 2487
  作者：Orndorff、Kennedy

  DOI：——

  日期：——