4-[(2,2-diethoxyethyl)thio]-1-methylpiperidine | 156756-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[(2,2-diethoxyethyl)thio]-1-methylpiperidine
• 英文别名: 4-(2,2-diethoxyethylsulfanyl)-1-methylpiperidine
• CAS: 156756-77-3
• 化学式: C₁₂H₂₅NO₂S
• 分子量: 247.402
• InChiKey: CXTIKSLHUXGAGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[(2,2-diethoxyethyl)thio]-1-methylpiperidine 在 盐酸 、 氨 、 sodium amide 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 生成 5-bromo-1-methyl-3-[(1-methylpiperidin-4-yl)thio]-1H-indole
  参考文献：
  名称：

  Novel 3-(4-piperidinylthio)-1 H -indoles as potent nonopioid orally active central analgesics

  摘要：

  A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00102-5
• 作为产物：
  描述：

  N-甲基-4-哌啶酮 在 硫化氢 、 sodium ethanolate 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 生成 4-[(2,2-diethoxyethyl)thio]-1-methylpiperidine
  参考文献：
  名称：

  Novel 3-(4-piperidinylthio)-1 H -indoles as potent nonopioid orally active central analgesics

  摘要：

  A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00102-5

文献信息

• Piperidinylthioindole derivatives, their methods of preparation and
  申请人：Laboratoires Upsa

  公开号：US05418242A1

  公开（公告）日：1995-05-23

  The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as drugs with analgesic properties.

  本发明涉及公式##STR1##的衍生物及其加合盐，以及它们在治疗学中的应用，特别是作为具有镇痛性质的药物。
• DERIVES DE PIPERIDINYL THIO INDOLE COMME ANTALGIQUES
  申请人：LABORATOIRES UPSA

  公开号：EP0699195A1

  公开（公告）日：1996-03-06
• AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY
  申请人：KOSMIN, Gerald, Emmanuel

  公开号：EP0711292A1

  公开（公告）日：1996-05-15
• US5317025A
  申请人：——

  公开号：US5317025A

  公开（公告）日：1994-05-31
• US5418242A
  申请人：——

  公开号：US5418242A

  公开（公告）日：1995-05-23