2,5-diethyl-piperazine | 23703-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,5-diethyl-piperazine
• 英文别名: 2,5-diethyl piperazine；2,5-diethylpiperazine；3,6-Diethyl-piperazin；2,5-Diethylpiperazin
• CAS: 23703-03-9
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: JIAOVIBEPXQRNK-UHFFFAOYSA-N

物化性质

• 熔点：
  72-73.5 °C
• 沸点：
  193-200 °C
• 密度：
  0.819±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5-diethyl-piperazine 在 potassium carbonate 、 三氟乙酸 、 sodium iodide 作用下， 以 乙醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 96.0h， 生成 1-[2-[2-[4-[2-[2-[Bis(2-hydroxydodecyl)amino]ethylsulfanyl]ethyl]-2,5-diethylpiperazin-1-yl]ethylsulfanyl]ethyl-(2-hydroxydodecyl)amino]dodecan-2-ol
  参考文献：
  名称：

  WO2024054901A1

  摘要：

  公开号：
• 作为产物：
  描述：

  (3S,6S)-3,6-diethylpiperazine-2,5-dione 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2,5-diethyl-piperazine
  参考文献：
  名称：

  WO2024054901A1

  摘要：

  公开号：

文献信息

• Process for preparing pyrazines from hydroxyamines
  申请人：TEXACO DEVELOPMENT CORPORATION

  公开号：EP0363532A1

  公开（公告）日：1990-04-18

  This invention relates to the reaction of hydroxyamines to form pyrazines by a process comprising reacting said hydroxyamine in the presence of a catalyst which may be a transition metal catalyst optionally containing an alkaline earth metal oxide, or alternatively the catalyst may be a rhodium, ruthenium or palladium-containing compound and a phosphine-containing compound.

  这项发明涉及羟基胺通过在催化剂存在下反应形成吡嗪的过程，该催化剂可以是含有碱土金属氧化物的过渡金属催化剂，或者催化剂可以是含有铑、钌或钯的化合物和含有磷化氢的化合物。
• N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20100197703A1

  公开（公告）日：2010-08-05

  This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.

  该发明提供了噻唑基哌嗪衍生物，以及包括苯基和苄基噻唑基哌啶衍生物的N-磺酰杂环衍生物，以及其药学上可接受的盐，这些是用于治疗α-突触核蛋白病的有效活性成分，如帕金森病、弥漫性小体病、创伤性脑损伤、肌萎缩侧索硬化症、尼曼-匹克病、哈勒沃登-施帕茨综合征、唐氏综合征、神经轴突萎缩、多系统萎缩和阿尔茨海默病的治疗方法。该发明还提供了制备这些衍生物的方法，以及包括这些衍生物和药学上可接受的辅料的药物组合物。
• Salts of triazinic compounds with phosphorus oxyacids, and use of said compounds in self-extinguishing polymeric compositions
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0537837A1

  公开（公告）日：1993-04-21

  Salts of triazinic compounds with phosphorus oxyacids, having the general formula (I): obtained by salifying oligomeric derivatives of 2,4, 6-triamino-1,3,5-triazine with a phosphorus-containing acid. The compounds with general formula (I) find use in particular as flame-retardant additives.

  三嗪化合物与含磷氧酸盐的盐，其一般式为(I)：通过用含磷酸盐对2,4,6-三氨基-1,3,5-三嗪的寡聚衍生物进行盐化而获得。具有一般式(I)的化合物特别用作阻燃添加剂。
• Salts of triazine compounds with cyanuric acid as flame retardants
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0550084A1

  公开（公告）日：1993-07-07

  Salts of triazine compounds with cyanuric acid, of general formula (I): obtained by salifying 2,4,6-triamino-1,3,5-triazine derivatives with cyanuric acid. The new salts of general formula (I) are used in particular as flame retardant additives.

  三嗪类化合物与三聚氰酸的盐，通式为(I)：通过使用三聚氰酸与2,4,6-三氨基-1,3,5-三嗪衍生物进行盐化反应而获得。新的通式(I)盐特别用作阻燃添加剂。
• Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders
  申请人：Yamashita Hiroshi

  公开号：US20090264404A1

  公开（公告）日：2009-10-22

  A heterocyclic compound or a salt thereof represented by the formula (1): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R 1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  一种杂环化合物或其盐，其化学式为（1）：其中R2代表氢原子或较低的烷基基团；A代表较低的烷基烯基基团；R1代表芳香族基团或杂环基团。本发明的化合物具有广泛的治疗精神障碍的谱，包括中枢神经系统障碍，无副作用且安全性高。