N-methyl [[(1-methylethyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)amino]thio]carbamoyl fluoride | 77600-83-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: N-methyl [[(1-methylethyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)amino]thio]carbamoyl fluoride
• 英文别名: N-methyl[[(isopropyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-amino]thio]carbamic fluoride；N-methyl[[(isopropyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)amino]thio]carbamic fluoride；N-methyl-N-[propan-2-yl-(2-sulfanylidene-1,3,2lambda5-dioxaphosphinan-2-yl)amino]sulfanylcarbamoyl fluoride；N-methyl-N-[propan-2-yl-(2-sulfanylidene-1,3,2λ5-dioxaphosphinan-2-yl)amino]sulfanylcarbamoyl fluoride
• CAS: 77600-83-0
• 化学式: C₈H₁₆FN₂O₃PS₂
• 分子量: 302.331
• InChiKey: KNVUWVFKSUJQDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  99.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-methyl [[(1-methylethyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)amino]thio]carbamoyl fluoride 、 syn(alkylthio)-S-Methyl-thiopropion-hydroximat 生成 methyl (1E)-N-[methyl-[propan-2-yl-(2-sulfanylidene-1,3,2λ5-dioxaphosphinan-2-yl)amino]sulfanylcarbamoyl]oxypropanimidothioate
  参考文献：
  名称：

  NELSON, S. J.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(isopropylamino)-2-thioxo-1,3,2-dioxaphosphorinane 、 N-methyl-carbamic acid fluoride 生成 N-methyl [[(1-methylethyl)(2-thioxo-1,3,2-dioxaphosphorinan-2-yl)amino]thio]carbamoyl fluoride
  参考文献：
  名称：

  NELSON, S. J.

  摘要：

  DOI：

文献信息

• Processes for making phosphorus derivatives of aminothiomethylcarbamates
  申请人：The Upjohn Company

  公开号：US04354975A1

  公开（公告）日：1982-10-19

  This invention pertains to novel processes for preparing phosphorus derivatives of aminothiomethylcarbamates using as intermediates corresponding phosphorus derivatives of aminothiocarbamic halides. The carbamates are useful as pesticides against insects, mites, and nematodes. Two processes for preparing the corresponding intermediates are described. One preparation generally reacts an appropriate N-chlorothiophosphoramide with N-methylcarbamoyl halide. The other preparation generally reacts an N-chlorothiomethylcarbamoyl halide with an appropriate phosphoramide. The intermediate will react with various alcohols to produce the desired carbamates in the process of the invention.

  本发明涉及使用相应的氨硫代氨基卡巴酸酯的磷衍生物作为中间体，制备氨硫代卡巴酸酯的新工艺。这些卡巴酸酯可用作杀虫剂，用于对抗昆虫、螨和线虫。文中描述了两种制备相应中间体的方法。一种制备方法通常是将适当的N-氯硫代磷酰胺与N-甲基氨基卡巴酰卤反应。另一种制备方法通常是将N-氯硫代甲基卡巴酰卤与适当的磷酰胺反应。该中间体将与各种醇反应，从而在本发明的过程中产生所需的卡巴酸酯。
• Phosphorus derivatives of aminothiocarbamoyl halides
  申请人：The Upjohn Company

  公开号：US04234521A1

  公开（公告）日：1980-11-18

  This invention pertains to novel phosphorus derivatives of aminothiocarbamic halides and processes for their preparation. The carbamic halides are readily prepared by two general procedures. In one procedure an appropriate N-(chlorothio)phosphorus amide reactant is readily prepared by reacting the corresponding phosphorus amide with sulfur dichloride which reactant will react with N-methylcarbamoyl halide so as to produce the corresponding object compounds of this invention. In a different procedure the same compounds that are the object of this invention are prepared by reacting an appropriate corresponding phosphorus amide with an N-chlorothiomethylcarbamoyl halide reactant which reactant is readily prepared by reacting N-methylcarbamoyl halide with sulfur chloride. The novel compounds of this invention are intermediates for the preparation of pesticides.

  这项发明涉及新型的氨基硫代氨基卡巴酸卤化物磷衍生物及其制备方法。卡巴酸卤化物可以通过两种一般程序轻松制备。在一种程序中，通过将相应的磷酰胺与二氯化硫反应，可以轻松制备适当的N-(氯硫)磷酰胺试剂，该试剂将与N-甲基氨基甲酰卤化物反应，从而产生本发明的相应目标化合物。在另一种程序中，通过将适当的相应磷酰胺与N-氯硫甲基氨基甲酰卤化物试剂反应，可以制备本发明的相同化合物，该试剂可以通过将N-甲基氨基甲酰卤化物与硫氯化物反应来轻松制备。本发明的新型化合物是制备农药的中间体。
• NELSON, S. J.
  作者：NELSON, S. J.

  DOI：——

  日期：——
• US4297285A
  申请人：——

  公开号：US4297285A

  公开（公告）日：1981-10-27