6-aminoindazole hydrochloride | 97763-34-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 6-aminoindazole hydrochloride
• 英文别名: 1(2)H-indazol-6-ylamine; hydrochloride；1(2)H-Indazol-6-ylamin; Hydrochlorid；1H-Indazol-6-amine, hydrochloride；1H-indazol-6-amine;hydrochloride
• CAS: 97763-34-3
• 化学式: C₇H₇N₃*ClH
• 分子量: 169.614
• InChiKey: NONMOCPCPXUMIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzylidene-(1(2)H-indazol-6-yl)-amine 、 6-aminoindazole hydrochloride 在 乙醇 作用下， 生成 5-phenyl-1,5,9,11-tetrahydro-dipyrazolo[4,3-b;3',4'-i]acridine
  参考文献：
  名称：

  Fries et al., Justus Liebigs Annalen der Chemie, 1942, vol. 550, p. 31,44

  摘要：

  DOI：

文献信息

• Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2116547A1

  公开（公告）日：2009-11-11

  The invention relates to compounds (I) having pharmacological activity towards the 5-HT6 receptor, and more particularly to some N-imidazo[2,1-b]thiazole-5-sulfonamide derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT6 is involved.

  该发明涉及具有对5-HT6受体具有药理活性的化合物(I)，更具体地涉及一些N-咪唑[2,1-b]噻唑酮-5-磺酰胺衍生物，以及制备这些化合物的方法，包括含有它们的药物组合物，以及它们用于治疗和/或预防涉及5-HT6的疾病。
• [EN] SUBSTITUTED N-IMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS<br/>[FR] DÉRIVÉS DE N-IMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE SUBSTITUÉS UTILISÉS COMME LIGANDS DE 5-HT6
  申请人：ESTEVE LABOR DR

  公开号：WO2009135925A1

  公开（公告）日：2009-11-12

  The invention relates to compounds (I) having pharmacological activity towards the 5-HT6 receptor, and more particularly to some N-imidazo[2,1-b]thiazole-5-sulfonamide derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT6 is involved.