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KSiPr | 51042-72-9

中文名称
——
中文别名
——
英文名称
KSiPr
英文别名
potassium isopropanethiolate;Potassium 2-propanethiolate;potassium;propane-2-thiolate
KSiPr化学式
CAS
51042-72-9
化学式
C3H7S*K
mdl
——
分子量
114.253
InChiKey
MFRLWXIEGOHANF-UHFFFAOYSA-M
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    -2.05
  • 重原子数:
    5
  • 可旋转键数:
    0
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    1
  • 氢给体数:
    0
  • 氢受体数:
    1

SDS

SDS:c7877d4cea7e7c89e2a646a5698bc0f4
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反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cr: Org.Verb., 1.6.1.2.1.5, page 216 - 218
    摘要:
    DOI:
  • 作为产物:
    描述:
    Potassium;(5-aminonaphthalen-1-yl)azanide 、 异丙硫醇二甲基亚砜dimsyl potassium 作用下, 生成 KSiPr1,5-萘二胺
    参考文献:
    名称:
    Stabilization of the monoanion of 1,8-diaminonaphthalene by intramolecular hydrogen bonding. A novel case of amide ion homoconjugation in a superbase solution
    摘要:
    DOI:
    10.1021/ja00365a075
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文献信息

  • Nitration of 5,11-dihydroindolo[3,2-<i>b</i>]carbazoles and synthetic applications of their nitro-substituted derivatives
    作者:Roman A Irgashev、Nikita A Kazin、Gennady L Rusinov、Valery N Charushin
    DOI:10.3762/bjoc.13.136
    日期:——
    A new general approach to double nitration of 6,12-di(hetero)aryl-substituted and 6,12-unsubstituted 5,11-dialkyl-5,11-dihydroindolo[3,2-b]carbazoles by acetyl nitrate has been developed to obtain their 2,8-dinitro and 6,12-dinitro derivatives, respectively. A formation of mono-nitro derivatives (at C-2 or C-6) from the same indolo[3,2-b]carbazoles has also been observed in several cases. Reduction
    已开发出一种新的通用方法,可通过乙酰硝酸酯双硝化6,12-二(杂)芳基取代的和6,12-未取代的5,11-二烷基-5,11-二氢吲哚[3,2-b]咔唑分别获得其2,8-二硝基和6,12-二硝基衍生物。在几种情况下,还观察到由相同的吲哚并[3,2-b]咔唑形成单硝基衍生物(在C-2或C-6处)。用锌粉和盐酸还原2-硝基和2,8-二硝基衍生物得到2-氨基-和2,8-二氨基取代的吲哚[3,2-b]咔唑,同时还原6,12-二硝基衍生物在相似的反应条件下,伴随着后者化合物的脱氮氢化为6,12-未取代的吲哚[3,2-b]咔唑。已证明仅在C-2处发生6,12-二硝基衍生物的甲酰化,这些化合物的溴化反应在吲哚[3,2-b]咔唑支架的C-2和C-8处都发生了。此外,已经通过与S-和N-亲核试剂反应改性了6,12-二硝基取代的吲哚[3,2-b]咔唑。值得注意的是,与吲哚或咔唑的钾盐仅引起一个硝基的取代不同,用硫醇钾处理6
  • Antithrombotic Ethers
    申请人:Franciskovich Jeffry Bernard
    公开号:US20080108594A1
    公开(公告)日:2008-05-08
    This application relates to a compound of formula I (or a pro-drug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
    本申请涉及公式I的化合物(或其前药或其药物可接受的盐),其制药组合物,以及其作为Xa因子和/或凝血酶抑制剂的用途,以及其制备过程和中间体(I)。
  • Antithrombotic ethers
    申请人:Eli Lilly and Company
    公开号:US07615568B2
    公开(公告)日:2009-11-10
    This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).
    本申请涉及一种I式化合物(或其前药或该化合物或前药的药学上可接受的盐),如本文所定义,以及其制药组合物,以及其作为Xa因子和/或凝血酶抑制剂的用途,以及其制备过程和中间体(I)。
  • Chang, Chaung-Sheng J.; Enemark, John H., Inorganic Chemistry, 1991, vol. 30, # 4, p. 683 - 688
    作者:Chang, Chaung-Sheng J.、Enemark, John H.
    DOI:——
    日期:——
  • New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 1. Synthesis and microbiological evaluation
    作者:A. Van Schepdael、J. Delcourt、M. Mulier、R. Busson、L. Verbist、H. J. Vanderhaeghe、M. P. Mingeot-Leclercq、P. M. Tulkens、P. J. Claes
    DOI:10.1021/jm00108a035
    日期:1991.4
    The clinical use of the potent, wide-spectrum aminoglycoside antibiotics is limited by oto- and nephrotoxicities. The latter is related to the binding of these polycationic drugs to negatively charged phospholipids and to the subsequent inhibition of lysosomal phospholipases. In order to explore the influence of a modification of the hydrophobic/hydrophilic balance at a specific site of an aminoglycoside, kanamycin B has been chemically modified in position 6" by substitution of the hydroxyl group with a halogen atom (or a pseudohalogen group), or an amino, an amido, a thioalkyl, or an alkoxy group, each series containing increasingly bulkier chains. Examination of the antibacterial activity of the synthesized compounds revealed a negative correlation between the size of the 6"-substituent and the antibacterial activity against kanamycin B sensitive Gram-positive and -negative organisms. Only derivatives with small substituents in position 6", namely chloro, bromo, azido, amino, methylcarbamido, acetamido, methylthio, methylsulfinyl, O-methyl, O-ethyl, and O-isopropyl, showed acceptable activity (geometric mean of minimum inhibitory concentrations for Gram-negative strains less-than-or-equal-to 2.5 mg/L; value for kanamycin B, 0.5 mg/L). In vitro toxicological evaluation of all derivatives and computer-aided conformational analysis of selected compounds inserted in a phosphatidylinositol monolayer are presented in the following paper in this issue.
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