3-(1H-咪唑-1-基)-哌啶 | 867007-94-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 3-(1H-咪唑-1-基)-哌啶
• 英文名称: 3-(1H-imidazol-1-yl)piperidine
• 英文别名: 3-imidazol-1-ylpiperidine
• CAS: 867007-94-1
• 化学式: C₈H₁₃N₃
• mdl: MFCD09998986
• 分子量: 151.211
• InChiKey: UYOZDXASYOYYCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-咪唑-1-吡啶 在 5%-palladium/activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 80.0 ℃ 、10.13 MPa 条件下， 反应 24.0h， 以95%的产率得到3-(1H-咪唑-1-基)-哌啶
  参考文献：
  名称：

  A Convenient Synthesis of (1H-Azol-1-yl)piperidines

  摘要：

  A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds.

  DOI：

  10.1055/s-0031-1291126

文献信息

• SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)
  申请人：Weintraub M. Philip

  公开号：US20070032489A1

  公开（公告）日：2007-02-08

  The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R 1 , R 2 , R 3 and R 4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

  本发明涉及一系列公式I的2,3,5-取代吡啶酮衍生物，其中R，R1，R2，R3和R4如本文所定义。本发明还涉及制备这些化合物的方法。本发明的化合物是聚腺苷酸二磷酸核糖聚合酶（PARP）的抑制剂，因此在治疗和/或预防各种疾病，包括与中枢神经系统和心血管疾病有关的疾病方面，具有药物学上的用途。
• COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER
  申请人：ARGONAUT THERAPEUTICS LIMITED

  公开号：US20200325128A1

  公开（公告）日：2020-10-15

  The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of proliferative diseases, such as cancer.
• US8173682B2
  申请人：——

  公开号：US8173682B2

  公开（公告）日：2012-05-08