1-benzyl-3,5-diphenylpiperidine-2,6-dione | 1357083-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-benzyl-3,5-diphenylpiperidine-2,6-dione
• CAS: 1357083-47-6
• 化学式: C₂₄H₂₁NO₂
• 分子量: 355.436
• InChiKey: TZOWOAQYYKFDQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 苯乙酸乙酯 、 苄胺 在 哌啶 、 吡啶 作用下， 以 乙醇 、 水 为溶剂， 反应 3.5h， 以82%的产率得到1-benzyl-3,5-diphenylpiperidine-2,6-dione
  参考文献：
  名称：

  Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents

  摘要：

  The present Letter describes a one-pot multi-component method that allows the efficient and mild preparation of 3,5-diphenylpiperidin-2,6-dione and a new series of 3,5-diarylpiperidin-2,6-dione derivatives from ethyl 2-arylacetates, formaldehyde and ammonia/aliphatic/aromatic amines. The structures of the compounds were elucidated by IR, NMR spectroscopic data and microanalyses. The anticonvulsant activities of these compounds were evaluated by maximal electroshock seizure test and were also evaluated for motor impairment. Among the synthesized compounds, 5a, 5b, 5d, and 5e could be considered potentially the most useful and safe therapeutic compound and 5g, 5i, 5j, 5m, and 5o exhibit potent activities. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.035

文献信息

• Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents
  作者：Mariappan Babu、Kasi Pitchumani、Penugonda Ramesh

  DOI：10.1016/j.bmcl.2011.11.035

  日期：2012.1

  The present Letter describes a one-pot multi-component method that allows the efficient and mild preparation of 3,5-diphenylpiperidin-2,6-dione and a new series of 3,5-diarylpiperidin-2,6-dione derivatives from ethyl 2-arylacetates, formaldehyde and ammonia/aliphatic/aromatic amines. The structures of the compounds were elucidated by IR, NMR spectroscopic data and microanalyses. The anticonvulsant activities of these compounds were evaluated by maximal electroshock seizure test and were also evaluated for motor impairment. Among the synthesized compounds, 5a, 5b, 5d, and 5e could be considered potentially the most useful and safe therapeutic compound and 5g, 5i, 5j, 5m, and 5o exhibit potent activities. (C) 2011 Elsevier Ltd. All rights reserved.