(R)-1-(benzofuran-2-yl)-N-propylpentan-2-amine hydrochloride | 265130-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (R)-1-(benzofuran-2-yl)-N-propylpentan-2-amine hydrochloride
• 英文别名: (2R)-1-(1-benzofuran-2-yl)-N-propylpentan-2-amine;hydrochloride
• CAS: 265130-22-1
• 化学式: C16H24ClNO
• 分子量: 281.82
• InChiKey: GKKNDWKXWAVGOK-PFEQFJNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-3,4-dipropyl-1,2,3-oxathiazolidine-2,2-dioxide 、 2,3-苯并呋喃 以52的产率得到(R)-1-(benzofuran-2-yl)-N-propylpentan-2-amine hydrochloride
  参考文献：
  名称：

  Process for preparing optically active aminopentane derivative, intermediate and process for preparing intermediate

  摘要：

  提供了一种制备光学活性氨基戊烷衍生物的方法，该衍生物可作为精神药物、抗抑郁药物、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等，一种新型光学活性中间体氧硫噻唑啉衍生物在氨基戊烷衍生物的生产中非常有用；以及生产该中间体的方法。光学活性氨基戊烷衍生物可以从式（5）所表示的新型光学活性氧硫噻唑啉衍生物中以工业上的优势方式生产出来：其中*表示R或S构型中的不对称碳原子的位置，n为0或1。

  公开号：

  US07807840B2

文献信息

• Process for preparing optically active aminopentane derivative, intermediate and process for preparing intermediate
  申请人：Fujimoto Co., Ltd.

  公开号：US07807840B2

  公开（公告）日：2010-10-05

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供了一种制备光学活性氨基戊烷衍生物的方法，该衍生物可作为精神药物、抗抑郁药物、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等，一种新型光学活性中间体氧硫噻唑啉衍生物在氨基戊烷衍生物的生产中非常有用；以及生产该中间体的方法。光学活性氨基戊烷衍生物可以从式（5）所表示的新型光学活性氧硫噻唑啉衍生物中以工业上的优势方式生产出来：其中*表示R或S构型中的不对称碳原子的位置，n为0或1。
• Process for Preparing Optically Active Aminopentane Derivative, Intermediate and Process for Preparing Intermediate
  申请人：Yoneda Fumio

  公开号：US20090124813A1

  公开（公告）日：2009-05-14

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供了一种制备光学活性氨基戊烷衍生物的方法，该衍生物可作为精神药物、抗抑郁药物、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等，一种新型光学活性中间体噁嗪硫脲环衍生物，非常有用于制备氨基戊烷衍生物；以及其生产方法。光学活性氨基戊烷衍生物可以从新型光学活性噁嗪硫脲环衍生物中工业上优势地生产，该噁嗪硫脲环衍生物的化学式表示为（5）：其中*表示R或S构型的不对称碳原子的位置，n为0或1。
• PROCESS FOR PREPARING OPTICALLY ACTIVE AMINOPENTANE DERIVATIVE, INTERMEDIATE AND PROCESS FOR PREPARING INTERMEDIATE
  申请人：Yoneda Fumio

  公开号：US20100324300A1

  公开（公告）日：2010-12-23

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供一种制备具有潜在作为精神药物、抗抑郁药、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等作用的光学活性氨基戊烷衍生物的方法；一种非常有用于氨基戊烷衍生物生产的新型光学活性内酰胺噻唑环衍生物；以及其生产方法。这些光学活性氨基戊烷衍生物可以从由式（5）表示的新型光学活性内酰胺噻唑环衍生物中以工业上的有利方式生产出来：其中*表示R或S构型的不对称碳原子的位置，n为0或1。
• PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPENTANE DERIVATIVE, INTERMEDIATE IN THE PROCESS AND PROCESS FOR PRODUCTION OF THE INTERMEDIATE
  申请人：Fujimoto Co., Ltd.

  公开号：EP1905760B1

  公开（公告）日：2011-10-26
• US7807840B2
  申请人：——

  公开号：US7807840B2

  公开（公告）日：2010-10-05