(S)-N-{3-[4-(4-cyanomethyl-piperidin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide | 648909-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (S)-N-{3-[4-(4-cyanomethyl-piperidin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
• 英文别名: (S)-N-(3-{4-[4-(cyanomethyl)piperidin-1-yl]-3-fluorophenyl}-2-oxooxazolidin-5-ylmethyl)acetamide；(S)-N-{3-[4-(4-cyanomethylpiperidin-1-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-ylmethyl}-acetamide；N-[[(5S)-3-[4-[4-(cyanomethyl)piperidin-1-yl]-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 648909-91-5
• 化学式: C₁₉H₂₃FN₄O₃
• 分子量: 374.415
• InChiKey: AAHQJKQDFPRNPZ-INIZCTEOSA-N

物化性质

• 沸点：
  647.3±50.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-N-{3-[4-(4-cyanomethyl-piperidin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 在 叠氮基三甲基硅烷 、 二正丁基氧化锡 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以66%的产率得到(S)-N-(3-{3-fluoro-4-[4-(1H-tetrazol-5-ylmethyl)-piperidin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide
  参考文献：
  名称：

  WO2007/23507

  摘要：

  公开号：

文献信息

• Antimicrobial oxazolifinones with improved pharmacokinetic profile and safety advantages
  申请人：——

  公开号：US20040235900A1

  公开（公告）日：2004-11-25

  The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyanoalkylpiperidinophenyl oxazolidinone derivatives having antimicrobial activity, favourable pharmacokinetic and safety profiles, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating microbial infections with the said derivatives.

  本发明提供了具有高抗微生物活性的药剂，用于预防和治疗传染病。因此，本发明提供了新型的具有抗微生物活性、药代动力学和安全性良好的氰基烷基哌啶基苯氧唑啉衍生物，制备该化合物的方法，以及含有该衍生物作为活性成分的抗微生物组合物和使用该衍生物治疗微生物感染的方法。
• Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
  申请人：Sindkhedkar Milind D

  公开号：US20090018123A1

  公开（公告）日：2009-01-15

  The present invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

  本发明涉及重组DNA，包括一个Salmonidae alphavirus的基因组RNA的cDNA，其前面有一个间隔序列，在适当的启动子控制下。这些重组DNA对于获得表达载体、产生重组的Salmonidae alphavirus以及获得疫苗非常有用。
• ANTIMICROBIAL OXAZOLIDINONES, PROCESS OF THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Wockhardt Limited

  公开号：EP1546140A2

  公开（公告）日：2005-06-29
• OXAZOLIDINONES BEARING ANTIMICROBIAL ACTIVITY COMPOSITION AND METHODS OF PREPARATION
  申请人：Wockhardt Limited

  公开号：EP1912980A2

  公开（公告）日：2008-04-23
• [EN] ANTIMICROBIAL OXAZOLIDINONES, PROCESS OF THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] OXAZOLIDINONES ANTI-MICROBIENNES A PROFIL PHARMACOCINETIQUE AMELIORE ET AVANTAGES DE SÛRETE
  申请人：CHUGH YATI

  公开号：WO2004007488A2

  公开（公告）日：2004-01-22

  The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyanoalkylpiperidinophenyl oxazolidinone derivatives having antimicrobial activity, favourable pharmacokinetic and safety profiles, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating microbial infections with the said derivatives.