3-Amino-chromanon-(4) | 20811-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-Amino-chromanon-(4)
• 英文别名: 4H-1-Benzopyran-4-one, 3-amino-2,3-dihydro-；3-amino-2,3-dihydrochromen-4-one
• CAS: 20811-42-1
• 化学式: C₉H₉NO₂
• mdl: MFCD09966057
• 分子量: 163.176
• InChiKey: GQGXWCHTYSBDRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20150111867A1

  公开（公告）日：2015-04-23

  The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

  本发明涉及氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物的化学式（I）或其生理耐受盐。该发明涉及包括这种氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物的药物组合物，以及利用这种氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物进行治疗目的的用途。这些氨基色酮、氨基硫代色酮和氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
• 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES
  申请人：Fukunaga Kenji

  公开号：US20090233918A1

  公开（公告）日：2009-09-17

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R 2 represents a hydrogen or the like; R 3 represents methyl group or the like; R 20 represents a halogen atom or the like; q represents an integer of 0 to 3; Z represent nitrogen atom, CH, or the like; R 4 represents hydrogen or the like; R 5 represents hydrogen or the like; R 6 represents a substituted alkyloxy and the like; p represents an integer of 0 to 3; X represents bond, CH 2 , oxygen atom, NH, or the like; any one or more of R 5 and R 6 , R 5 and R 4 , R 6 and R 4 , X and R 5 , X and R 4 , X and R 6 , and R 6 and R 6 may combine to each other to form a ring, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I），其手性异构体或药物可接受的盐：其中，R2代表氢或类似物；R3代表甲基基团或类似物；R20代表卤素原子或类似物；q表示0到3的整数；Z代表氮原子，CH或类似物；R4代表氢或类似物；R5代表氢或类似物；R6代表取代的烷氧基或类似物；p表示0到3的整数；X代表键，CH2，氧原子，NH或类似物；R5和R6，R5和R4，R6和R4，X和R5，X和R4，X和R6以及R6和R6中的任何一个或多个可以结合形成环，用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，例如神经退行性疾病（例如阿尔茨海默病）。
• AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
  申请人：AMBERG Wilhelm

  公开号：US20130035323A1

  公开（公告）日：2013-02-07

  The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

  本发明涉及公式(I)的氨基色素、氨基硫色素和氨基-1,2,3,4-四氢喹啉衍生物或其生理耐受的盐。本发明涉及包含此类氨基色素、氨基硫色素和氨基-1,2,3,4-四氢喹啉衍生物的制药组合物，以及使用此类氨基色素、氨基硫色素和氨基-1,2,3,4-四氢喹啉衍生物进行治疗的用途。氨基色素、氨基硫色素和氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
• Antiinflammatory and/or analgesic 3,4-dihydro(or 1,4-dihydro)-2-((substituted)thiol)-(1)-benzopyrano(3,4-d)imidazoles and their corresponding sulfoxides and sulfones
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0057932A1

  公开（公告）日：1982-08-18

  3,4-Dihydro(or 1,4-dihydro)-2-[(substituted)-thio]-[1]-benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones, such as 3,4-dihydro-(or 1,4-dihydro)-4-phenyl-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]-[1]benzopyrano[3,4-d]imidazole, are useful in the treatment of inflammation and/or pain.

  3,4-二氢（或 1,4-二氢）-2-[（取代）-硫代]-[1]-苯并吡喃并[3,4-d]咪唑及其相应的亚砜和砜，如 3,4-二氢-（或 1、4-苯基-2-[(1,1,2,2-四氟乙基)磺酰基]-[1]苯并吡喃并[3,4-d]咪唑，可用于治疗炎症和/或疼痛。
• Antiinflammatory and/or analgesic 1,8-dihydro (or 3,8-dihydro)-8-aryl-2-((substituted)thio)-indeno(1,2-)imidazoles and their corresponding sulfoxides and sulfones
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0061712A1

  公开（公告）日：1982-10-06

  1,8-Dihydro(or 3,8-dihydro)-8-aryl-2-[(substituted) thio]indeno[1,2-d]imidazoles and their corresponding sulfoxides and sulfones, such as 1,8-dihydro-(or 3,8-dihydro) -8-phenyl-2-[(1,1,2,2-tetrafluoroethyl)sulfonyl]indeno [1,2-d]imidazole, are useful in the treatment of inflammation and/or pain. Relationship to other applications This application is a continuation-in-part of copending application Serial No. 248,010, filed March 26, 1981.

  1,8-二氢（或 3,8-二氢）-8-芳基-2-[（取代）硫代]茚并[1,2-d]咪唑及其相应的亚砜和砜，如 1,8-二氢-（或 3,8-二氢）-8-苯基-2-[（1,1,2,2-四氟乙基）磺酰基]茚并[1,2-d]咪唑，可用于治疗炎症和/或疼痛。 与其他申请的关系 本申请是1981年3月26日提交的序列号为248,010的共同申请的部分延续。