2-(piperazin-1-yl)-4,6-di(piperidin-1-yl)-1,3,5-triazine | 421576-36-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(piperazin-1-yl)-4,6-di(piperidin-1-yl)-1,3,5-triazine
• 英文别名: 4-Piperazinyl-2,6-dipiperidyl-1,3,5-triazine；2-piperazin-1-yl-4,6-di(piperidin-1-yl)-1,3,5-triazine
• CAS: 421576-36-5
• 化学式: C₁₇H₂₉N₇
• mdl: MFCD02632042
• 分子量: 331.464
• InChiKey: OURNSQBCMZOFSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-((7-chloroquinolin-4-yl)amino)ethyl methanesulfonate 、 2-(piperazin-1-yl)-4,6-di(piperidin-1-yl)-1,3,5-triazine 在 N-甲基吡咯烷酮 作用下， 反应 0.01h， 生成 7-chloro-N-(2-(4-(4,6-di(piperidin-1-yl)-1,3,5-triazin-2-yl)piperazin-1-yl)ethyl)quinolin-4-amine
  参考文献：
  名称：

  Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents

  摘要：

  The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new class of hybrid 4-aminoquinoline triazines were synthesized and screened against CQ sensitive strain 3D7 of P. falciparum in an in vitro model. Compounds 65 and 69 exhibited more than 99% suppression on day 4 and on day 6 post treatment, compound 69 showed impressive 99.11% suppression against CQ resistant strain N-67 of P. yoelii in an in vivo assay. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.049
• 作为产物：
  描述：

  2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine 在 potassium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 生成 2-(piperazin-1-yl)-4,6-di(piperidin-1-yl)-1,3,5-triazine
  参考文献：
  名称：

  二，三取代的1,3,5-三嗪的设计，合成，抗菌活性及构效关系

  摘要：

  由于大量产生抗药性微生物，迫切需要开发新型化学治疗剂。在继续我们从1,3,5-三嗪发现新型杂环支架的研究的过程中，本研究涉及一些新型的二和三取代的1,3,5-三嗪衍生物的设计和开发。标题类似物的合成通过SNAr反应完成，然后针对一组代表性的革兰氏阴性和革兰氏阳性细菌进行严格的抗菌筛选。筛选结果表明，微小的结构变异可能会引起活性的急剧变化。胺桥和哌嗪被称为生物活性的产生和升级所必需的关键结构片段。

  DOI：

  10.2174/157018012799129846

文献信息

• A Convenient Synthesis of Triazine-Based Dendrons and Dendrimers via a Convergent Approach and a Study of Their Interactions with Tetrafluoro­benzoquinone
  作者：Long-Li Lai、Hui-Chu Hsu、Shun-Ju Hsu、Kung-Lung Cheng

  DOI：10.1055/s-0030-1258220

  日期：2010.10

  efficient and convergent approach to prepare triazine-based dendrons and dendrimers is developed. The steric hindrance resulting from the presence of dioctylamino moieties in the peripheral regions allows the synthesis of soluble dendrons without employing protection and deprotection steps. The triazine-based dendrimers are prepared via reaction of N,N′-dimethylethane-1,2-diamine with the dendrons in a ratio

  开发了一种方便，有效和收敛的方法来制备基于三嗪的树枝状和树枝状聚合物。由外围区域中二辛基氨基部分的存在引起的空间位阻允许不使用保护和脱保护步骤而合成可溶性树突。三嗪基树状聚合物是通过N，N'-二甲基乙烷-1,2-二胺与树突以1：2的比例反应制备的。树枝状聚合物与四氟苯醌的相互作用导致在吸收光谱中出现新的宽频带，红移了大约180 nm。 树突-树状聚合物-会聚方法-三嗪-四氟苯醌
• Antimalarial activity and docking studies of novel bi-functional hybrids derived from 4-aminoquinoline and 1,3,5-triazine against wild and mutant malaria parasites as pf-DHFR inhibitor
  作者：Hans Raj Bhat、Udaya Pratap Singh、Prashant Gahtori、Surajit Kumar Ghosh、Kabita Gogoi、Anil Prakash、Ramendra K. Singh

  DOI：10.1039/c2ra21915h

  日期：——

  Bi-functional conjugates comprised of 4-aminoquinoline and 1,3,5-triazine were synthesized through facile synthetic routes. These compounds were rigorously screened for determination of their antimalarial activity against wild and mutant cultured Plasmodium falciparum. The results disclosed that the conjugates have considerable antimalarial activity against both wild and mutant parasites with marked variation on changing the pattern of substitutions. The observed activity profiles were additionally substantiated by docking studies on both wild and quadruple mutant P. falciparum dihydrofolate reductase thymidylate synthase (pf-DHFR-TS).

  通过简便的合成路线合成了由 4-氨基喹啉和 1,3,5-三嗪组成的双功能共轭物。对这些化合物进行了严格筛选，以确定它们对野生和变异培养的恶性疟原虫的抗疟活性。结果表明，这些共轭物对野生寄生虫和变异寄生虫都具有相当强的抗疟活性，而且随着取代模式的改变而发生明显变化。此外，对野生和四重突变的恶性疟原虫二氢叶酸还原酶胸苷酸合成酶（pf-DHFR-TS）进行的对接研究也证实了观察到的活性特征。
• Polytriazinyl Compounds as Flame Retardants and Light Stabilizers
  申请人：Kaul Bansi Lal

  公开号：US20090281215A1

  公开（公告）日：2009-11-12

  Compounds consisting of an oligomer or a polymer of a 1,3,5-triazine derivative, having the general formula I: wherein: X is selected from: or X is a heterocyclic radical containing in the ring at least one nitrogen atom which radical is linked to the triazine ring through one of such nitrogen atoms, R 2 is alkyl or cycloalkyl, R 1 is a divalent radical of piperazine of the formula or R 2 is a divalent radical according to the formula or R 2 is a radical according to the formula Y n is an integer from 2 to 30, inclusive, m is an integer from 2 to 6, inclusive, p is an integer from 2 to 12, inclusive, and X 1 ═OH,NH 2 or X whereby X and X 1 may be the same or different, and, X 2 ═H or is a C 1 -C 4 alkyl group, and a solvent-free process for the production of the compounds of Formula I as well as the use of the self-extinguishing oligomeric or polymeric compounds as flame retardants and light stabilizers in thermoplastic polymers such as polypropylene or regenerated cellulose or polyester.
• POLYTRIAZINYL COMPOUNDS AS FLAME RETARDANTS AND LIGHT STABILIZERS
  申请人：Kaul Bansi Lal

  公开号：US20120071594A1

  公开（公告）日：2012-03-22

  Compounds consisting of an oligomer or a polymer of a 1,3,5-triazine derivative, having the general formula I: and a solvent-free process for the production of the compounds of Formula I as well as the use of the self-extinguishing oligomeric or polymeric compounds as flame retardants and light stabilizers in thermoplastic polymers such as polypropylene or regenerated cellulose or polyester.
• US8202924B2
  申请人：——

  公开号：US8202924B2

  公开（公告）日：2012-06-19