(2R,2''S)-2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)pyrrolidine hydrochloride | 1132649-86-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: (2R,2''S)-2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)pyrrolidine hydrochloride
• 英文别名: (2S)-2-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]pyrrolidine
• CAS: 1132649-86-5
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: BEVPGWLTKJHBHS-CABZTGNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以93%的产率得到(2R,2''S)-2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)pyrrolidine hydrochloride
  参考文献：
  名称：

  5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: Synthesis of all the stereoisomers and α4β2 nicotinic affinity

  摘要：

  The four stereoisomers of 2-oxazolidinone 5-substituted with 1-methyl-2-pyrrolidinyl (1), of 1,4-benzodioxane 2-substituted with the same residue (2) and of the nor-methyl analogue of this latter (2a) were synthesized as candidate nicotinoids. Of the 12 compounds, two N-methylated pyrrolidinyl-benzodioxane stereoisomers, namely those with the same relative configuration at the pyrrolidine stereocentre as (S)-nicotine, bind at alpha 4 beta 2 nicotinic acetylcholine receptor with submicromolar affinity. Consistently with the biological data, docking analysis enlightens significant differences in binding site interactions not only between 1 and 2, but also between 2 and 2a and between the stereoisomers of 2 accounting for the critical role played, in the case of the pyrrolidinyl-benzodioxanes, by the chirality of both the stereolabile and stereostable stereogenic atoms, namely the protonated tertiary nitrogen and the two asymmetric carbons. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.002

文献信息

• 5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: Synthesis of all the stereoisomers and α4β2 nicotinic affinity
  作者：Marco Pallavicini、Cristiano Bolchi、Matteo Binda、Antonio Cilia、Francesco Clementi、Rossana Ferrara、Laura Fumagalli、Cecilia Gotti、Milena Moretti、Alessandro Pedretti、Giulio Vistoli、Ermanno Valoti

  DOI：10.1016/j.bmcl.2008.12.002

  日期：2009.2

  The four stereoisomers of 2-oxazolidinone 5-substituted with 1-methyl-2-pyrrolidinyl (1), of 1,4-benzodioxane 2-substituted with the same residue (2) and of the nor-methyl analogue of this latter (2a) were synthesized as candidate nicotinoids. Of the 12 compounds, two N-methylated pyrrolidinyl-benzodioxane stereoisomers, namely those with the same relative configuration at the pyrrolidine stereocentre as (S)-nicotine, bind at alpha 4 beta 2 nicotinic acetylcholine receptor with submicromolar affinity. Consistently with the biological data, docking analysis enlightens significant differences in binding site interactions not only between 1 and 2, but also between 2 and 2a and between the stereoisomers of 2 accounting for the critical role played, in the case of the pyrrolidinyl-benzodioxanes, by the chirality of both the stereolabile and stereostable stereogenic atoms, namely the protonated tertiary nitrogen and the two asymmetric carbons. (C) 2008 Elsevier Ltd. All rights reserved.