Thiourea, N-(2,2-dimethyl-2H-1-benzopyran-6-yl)-N'-phenyl- | 896111-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Thiourea, N-(2,2-dimethyl-2H-1-benzopyran-6-yl)-N'-phenyl-
• 英文别名: 1-(2,2-dimethylchromen-6-yl)-3-phenylthiourea
• CAS: 896111-42-5
• 化学式: C₁₈H₁₈N₂OS
• 分子量: 310.4
• InChiKey: LRMGHFLCGDSSLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  65.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel Benzopyran Derivatives Having Inhibitory Activities Against Liver Fibrosis and Cirrhosis and Their Pharmaceutical Uses
  申请人：Gong Young-Dae

  公开号：US20090118302A1

  公开（公告）日：2009-05-07

  The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
• US8048912B2
  申请人：——

  公开号：US8048912B2

  公开（公告）日：2011-11-01