Urea, N'-(1,1-dimethylethyl)-N-(2-hydroxyethyl)-N-(2-hydroxypropyl)- | 885024-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Urea, N'-(1,1-dimethylethyl)-N-(2-hydroxyethyl)-N-(2-hydroxypropyl)-
• 英文别名: 3-tert-butyl-1-(2-hydroxyethyl)-1-(2-hydroxypropyl)urea
• CAS: 885024-89-5
• 化学式: C₁₀H₂₂N₂O₃
• 分子量: 218.296
• InChiKey: TXDXRHGRYPYKHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三氟化硼丁醚络合物 、 lithium 、 Urea, N'-(1,1-dimethylethyl)-N-(2-hydroxyethyl)-N-(2-hydroxypropyl)- 以 四氢呋喃 为溶剂， 反应 13.0h， 以87%的产率得到
  参考文献：
  名称：

  CN114573620

  摘要：

  公开号：

文献信息

• Composition comprising a urea compound
  申请人：Fonolla Moreno Angeles

  公开号：US20060111490A1

  公开（公告）日：2006-05-25

  Composition containing, in an aqueous medium, at least one compound of formula (I) described in the specification and its salts, solvates and isomers, and at least one polymer containing at least one monomer having a sulfonic group. The polymer may be in free or partially or totally neutralized form and it may be crosslinked or non-crosslinked. It may be a homopolymer or a copolymer, possibly containing hydrophobic groups. The invention composition is particularly useful in the fields of cosmetics and dermatology, especially for caring for, treating, cleansing and making up the skin and mucous membranes.

  在水性介质中，含有至少一种本说明书所述的式 (I) 化合物及其盐类、溶剂和异构体，以及至少一种含有至少一种具有磺酸基的单体的聚合物的组合物。聚合物可以是游离的，也可以是部分或完全中和的，可以是交联的，也可以是非交联的。它可以是均聚物或共聚物，可能含有疏水基团。本发明的组合物尤其适用于化妆品和皮肤科领域，特别是皮肤和粘膜的护理、治疗、清洁和化妆。
• Administration of urea compounds for combating signs of cutaneous aging
  申请人：Bernard Dominique

  公开号：US20060127343A1

  公开（公告）日：2006-06-15

  Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C 1 -C 4 alkyl radical or a C 2 -C 6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

  通过向需要此类治疗的个体施用一种化妆品/药物组合物，可预防和/或减少皮肤和/或粘膜的老化迹象，并刺激角质层蛋白水解酶的活性，该组合物包含有效量的至少一种具有下式（I）的羟基脲化合物： 其中 基团 R1、R2、R3 和 R4（可以相同或不同）分别是氢原子、C 1 -C 4 烷基或 C 2 -C 6 羟烷基，其中 R1 至 R4 自由基中至少有一个代表羟烷基，或其盐、溶液或异构体，配制成生理上可接受的介质。
• Sunscreen compositions comprising insoluble organic UV-screening agents and hydroxyalkylurea compounds
  申请人：Candau Didier

  公开号：US20060177394A1

  公开（公告）日：2006-08-10

  Cosmetic, notably anti-sun/sunscreen compositions having improved comfort after application onto keratin materials, e.g., human skin, contain at least one system for screening out UV radiation, and also contain: (a) at least one insoluble organic UV-screening agent, and (b) at least one hydroxyalkylurea compound of formula (I): in which R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, a C 1 -C 4 alkyl radical or a C 2 -C 6 hydroxyalkyl radical containing from 1 to 5 hydroxyl groups, at least one of the radicals R 1 -R 4 representing a hydroxyalkyl group, or salt, solvate or isomer thereof, formulated into (c) a topically applicable, cosmetically acceptable carrier therefor.

  化妆品，特别是防晒/防晒霜组合物，在涂抹到角质材料（如人类皮肤）上后，可改善其舒适性，该组合物至少含有一种紫外线辐射屏蔽系统，还含有： (a) 至少一种不溶性有机紫外线屏蔽剂，以及 (b) 至少一种式 (I) 的羟基烷基脲化合物： 其中 R 1 , R 2 , R 3 和 R 4 各自独立地代表一个氢原子、一个 C 1 -C 4 烷基或 C 2 -C 6 含有 1 至 5 个羟基的羟烷基，其中至少一个基 R 1 -R 4 代表羟烷基的基团，或其盐、溶液或异构体，配制成 (c) 可局部使用的、美容上可接受的载体。
• Nanoemulsion containing a hydroxylated urea compound
  申请人：Simonnet Jean-Thierry

  公开号：US20060193813A1

  公开（公告）日：2006-08-31

  The invention relates to an oil-in-water nanoemulsion having an oily phase dispersed in an aqueous phase, the oil globules of which have a number-average size of less than 100 nm, containing: (i) at least one amphiphilic lipid comprising at least one nonionic amphiphilic lipid, and optionally at least one ionic amphiphilic lipid, the oily phase and the amphiphilic lipid being present at a content such that the oily phase/amphiphilic lipid weight ratio ranges from 3 to 10, and (ii) at least one hydroxylated urea derivative. Application in cosmetics, dermatology, and ophthalmology.

  本发明涉及一种水包油型纳米乳液，其油相分散在水相中，油球的平均粒径小于 100 nm，含有：(i) 至少一种亲水脂质，包括至少一种非离子亲水脂质和可选的至少一种离子亲水脂质，油相和亲水脂质的含量应使油相/亲水脂质的重量比在 3-10 之间，以及 (ii) 至少一种羟基脲衍生物。应用于化妆品、皮肤科和眼科。
• Sunscreen compositions comprising lipophilic UV-screening agents and hydroxyalkylurea compounds
  申请人：Candau Didier

  公开号：US20060177393A1

  公开（公告）日：2006-08-10

  Cosmetic, notably anti-sun/sunscreen compositions having increased sun protection effectiveness and improved distribution over keratin materials, e.g., human skin, contain at least one fatty phase and at least one system for screening out UV radiation, and also contain: (a) at least one lipophilic UV-screening agent, and (b) at least one hydroxyalkylurea compound of formula (I): in which R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, a C 1 -C 4 alkyl radical or a C 2 -C 6 hydroxyalkyl radical containing from 1 to 5 hydroxyl groups, at least one of the radicals R 1 -R 4 representing a hydroxyalkyl group, or salt, solvate or isomer thereof, formulated into (c) a topically applicable, cosmetically acceptable carrier therefor.

  化妆品，特别是防晒/防晒霜组合物，具有更高的防晒效果和更好的在角质材料（如人 类皮肤）上的分布，含有至少一种脂肪相和至少一种屏蔽紫外线辐射的体系，还含有： (a) 至少一种亲脂性紫外线屏蔽剂，和 (b) 至少一种式 (I) 的羟基烷基脲化合物： 其中 R 1 , R 2 , R 3 和 R 4 各自独立地代表一个氢原子、一个 C 1 -C 4 烷基或 C 2 -C 6 含有 1 至 5 个羟基的羟烷基，其中至少一个基 R 1 -R 4 代表羟烷基的基团，或其盐、溶液或异构体，配制成 (c) 可局部使用的、美容上可接受的载体。