13,13-Dibutyl-10,16-bis(3,4,5-trifluorophenyl)-13-azoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene | 851942-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 13,13-Dibutyl-10,16-bis(3,4,5-trifluorophenyl)-13-azoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene
• CAS: 851942-93-3
• 化学式: C42H36F6N+
• 分子量: 668.7
• InChiKey: SKWHGISTYZJJIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.8
• 重原子数：
  49
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] ASYMMETRIC SYNTHESIS FOR PREPARING FLUOROLEUCINE ALKYL ESTERS<br/>[FR] SYNTHÈSE ASYMÉTRIQUE POUR PRÉPARER DES ESTERS D'ALKYLE DE FLUOROLEUCINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013148550A1

  公开（公告）日：2013-10-03

  The instant invention describes a novel asymmetric synthesis of fluoroleucine alkyl esters which utilizes allylation of a glycine derivative containing an imine moiety in the presence of a phase transfer catalyst and a solid additive, followed by fluorination of the alpha-allyl product so obtained, with a fluorinating agent such as Olah's reagent.

  这个发明描述了一种新颖的氟亮氨酸烷基酯的不对称合成方法，该方法利用含有亚胺基团的甘氨酸衍生物的烯丙基化，在相转移催化剂和固体添加剂的存在下进行，然后用氟化试剂（例如Olah试剂）对所得到的α-烯丙基产物进行氟化。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 1-AMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID ESTER
  申请人：Aikawa Toshiaki

  公开号：US20120130116A1

  公开（公告）日：2012-05-24

  1-Amino-2-vinylcyclopropanecarboxylic acid ester, which is useful as a synthetic intermediate of pharmaceuticals, can be produced by a process of producing 1-amino-2-vinylcyclopropanecarboxylic acid ester represented by formula (4): including a step of hydrolysis of an optically active 1-N-(arylmethylene)amino-2-vinylcyclopropanecarboxylic acid ester represented by formula (3): which is obtained by reacting an N-(arylmethylene)glycine ester represented by formula (1): with a compound represented by formula (2): in the presence of a base and an optically active quaternary ammonium salt.

  1-氨基-2-乙烯基环丙烷羧酸酯是一种用作制药合成中间体的化合物，可以通过以下步骤制备：首先，将化合物（2）与代表式（1）的N-(芳基亚甲基)甘氨酸酯在碱和手性季铵盐的存在下反应，得到代表式（3）的手性1-N-(芳基亚甲基)氨基-2-乙烯基环丙烷羧酸酯；然后，对该化合物进行水解反应，得到代表式（4）的1-氨基-2-乙烯基环丙烷羧酸酯，该化合物可用作制药合成中间体。
• PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF
  申请人：Maruoka Keiji

  公开号：US20090054679A1

  公开（公告）日：2009-02-26

  The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of α-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.

  本发明提供了一种使用醛亚胺型席夫碱制备α-氨基酸的不对称单取代烷基化合物的方法，其由特定的公式表示。在本发明的方法中，通过在存在光学活性季铵盐相转移催化剂和无机碱的介质中烷基化醛亚胺型席夫碱的过程，随后在达到化学计量反应完成时间之前的时间中止反应，从而可以获得具有高光学纯度的单取代烷基化产物。
• Optically active dibenzazepine derivatives
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2264038B1

  公开（公告）日：2016-01-06
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING alpha-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：Maruoka Keiji

  公开号：US20070135654A1

  公开（公告）日：2007-06-14

  The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-binaphthyl derivative, which can be produced by a relatively small number of processes, with an easily available secondary amine. This compound (I) is useful as a chiral phase-transfer catalyst.