(8R,9S,10S)-1,11-Bis-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undecan-5-one | 1026160-67-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (8R,9S,10S)-1,11-Bis-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undecan-5-one
• 英文别名: (8R,9S,10S)-1,11-bis[[tert-butyl(diphenyl)silyl]oxy]-9-hydroxy-8,10-dimethylundecan-5-one
• CAS: 1026160-67-7
• 化学式: C₄₅H₆₂O₄Si₂
• 分子量: 723.156
• InChiKey: CSPDTYUJNBDJLA-YWYFBRAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.29
• 重原子数：
  51
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (8R,9S,10S)-1,11-Bis-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undecan-5-one 在 四丁基氟化铵 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 (S)-2-((2S,3R,6R)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)propan-1-ol
  参考文献：
  名称：

  Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals

  摘要：

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01929-8
• 作为产物：
  描述：

  (Z)-(8R,9S,10S)-1,11-Bis-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undec-6-en-5-one 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.0h， 生成 (8R,9S,10S)-1,11-Bis-(tert-butyl-diphenyl-silanyloxy)-9-hydroxy-8,10-dimethyl-undecan-5-one
  参考文献：
  名称：

  Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals

  摘要：

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01929-8

文献信息

• Formation of dissymmetric eight-membered silalketals by ring-closing metathesis and their conversion to spiroketals
  作者：Jean-Guy Boiteau、Pierre Van de Weghe、Jacques Eustache

  DOI：10.1016/s0040-4039(00)01929-8

  日期：2001.1

  Eight-membered unsymmetrical silalketals are formed by RCM of mixed allyl/homoallyl silalketals. They are crucial intermediates in a short synthetic sequence to spiroketals illustrated in this paper by the synthesis of the C-28-C-38 portion of okadaic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.