1-methyl-octahydro-indolizine | 90948-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: 1-methyl-octahydro-indolizine
• 英文别名: 1-Methyl-octahydro-indolizin；Methylindolizidine；1-methyl-1,2,3,5,6,7,8,8a-octahydroindolizine
• CAS: 90948-99-5
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: URKQDKOCRHJMIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-octahydro-indolizine 、 氢溴酸 生成 (1R,8aR)-1-methyl-1,2,3,5,6,7,8,8a-octahydroindolizine;hydrobromide
  参考文献：
  名称：

  MIYANO, SEIJI;FUJII, SHIMICHIRO;YAMASHITA, OSAMU;TORAISHI, NAOKO;SUMOTO, +, J. HETEROCYCL. CHEM., 1982, 19, N 6, 1465-1468

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 铂 作用下， 生成 1-methyl-octahydro-indolizine
  参考文献：
  名称：

  314.八氢吡咯啉和八氢吡咯啉系列的合成

  摘要：

  DOI：

  10.1039/jr9370001518

文献信息

• [EN] NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND &bgr;-LACTAMASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS BICYCLIQUES ET LEUR UTILISATION EN TANT QU'AGENTS ANTIBACTÉRIENS ET INHIBITEURS DE &Bgr;-LACTAMASE
  申请人：NAEJA PHARMACEUTICAL INC

  公开号：WO2014091268A1

  公开（公告）日：2014-06-19

  A compound of formula (I), wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1 or NR2R3, and R1,R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.

  式（I）的化合物，其中：M为氢或药用可接受的盐形成阳离子；Y为OR1或NR2R3，R1、R2、R3和M如本文所定义。此外，治疗细菌感染的方法，制药组合物，分子复合物和制备化合物的方法。
• ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
  申请人：SCHWINK Lothar

  公开号：US20070197584A1

  公开（公告）日：2007-08-23

  The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.

  该发明涉及公式I的芳基取代的多环胺，特别是双环胺，以及其生理耐受的盐和生理功能衍生物；其中符号和基团在描述中有解释，还涉及使用这些化合物的药物组合物和医疗治疗。
• The generation and cyclisation of pyridinium radicals as a potential route to indolizidine alkaloids
  作者：Adrian P. Dobbs、Keith Jones、Ken T. Veal

  DOI：10.1016/s0040-4039(97)01178-7

  日期：1997.7

  The cyclisation of pyridine radicals derived from 2-bromo-N-alkyl pyridinium salts is described. The subsequent hydrogenation of the pyridinium salts is shown to give both the indolizidine and quinolizidine skeletons.

  描述了衍生自2-溴-N-烷基吡啶鎓盐的吡啶基的环化。吡啶鎓盐的随后氢化显示出同时得到了吲哚唑烷和喹喔啉骨架。
• USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090258872A1

  公开（公告）日：2009-10-15

  The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description.

  本发明涉及公式I的芳基取代多环胺的治疗用途，特别是双环胺，以及其生理上耐受的盐和生理上功能性衍生物；其中符号和基团在说明中解释。
• NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090082391A1

  公开（公告）日：2009-03-26

  The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物，以及其生理耐受盐和生理功能衍生物、其制备方法、至少包含本发明中的一种氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及将本发明中的氨基醇取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂的用途。