(1S,2S)-2-[[(1R)-2-methoxy-1-phenylethyl]amino]-1,2-diphenylethanol | 144302-39-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1S,2S)-2-[[(1R)-2-methoxy-1-phenylethyl]amino]-1,2-diphenylethanol
• CAS: 144302-39-6
• 化学式: C₂₃H₂₅NO₂
• 分子量: 347.457
• InChiKey: WWFPWWMIDDXAKI-VABKMULXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (R)-(-)-2-甲氧基-1-苯乙胺 在 甲醇 、 oxonium 作用下， 生成 (1S,2S)-2-[[(1R)-2-methoxy-1-phenylethyl]amino]-1,2-diphenylethanol
  参考文献：
  名称：

  Zirconium-mediated diastereoselective coupling reactions of chiral aldimine: Remarkable temperature-dependence of chiral induction

  摘要：

  Zr-Mediated coupling reactions of aldehyde with chiral aldimine which is derived from benzaldehyde and (R)-phenylglycinol methyl ether showed a remarkable temperature effect on the sense of chiral induction to yield amino alcohol derivatives with high diastereoselectivities.

  DOI：

  10.1016/s0040-4039(00)60112-0

文献信息

• Zirconium-mediated diastereoselective coupling reactions of chiral aldimine: Remarkable temperature-dependence of chiral induction
  作者：Hisanaka Ito、Takeo Taguchi、Yuji Hanzawa

  DOI：10.1016/s0040-4039(00)60112-0

  日期：1992.7

  Zr-Mediated coupling reactions of aldehyde with chiral aldimine which is derived from benzaldehyde and (R)-phenylglycinol methyl ether showed a remarkable temperature effect on the sense of chiral induction to yield amino alcohol derivatives with high diastereoselectivities.