Lasofoxifene 2-Oxide | 366017-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Lasofoxifene 2-Oxide
• 英文别名: 1-[2-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenoxy]ethyl]pyrrolidin-2-one
• CAS: 366017-88-1
• 化学式: C₂₈H₂₉NO₃
• 分子量: 427.5
• InChiKey: YBFAWBLHDMBREC-NAKRPHOHSA-N

物化性质

• 沸点：
  628.2±55.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• VAGINAL DELIVERY SYSTEMS CONTAINING SELECTIVE ESTROGEN RECEPTOR MODULATOR (SERM) AND USES THEREOF
  申请人：Azure Biotech, Inc.

  公开号：US20170333394A1

  公开（公告）日：2017-11-23

  The present disclosure provides pharmaceutical compositions that include one or more selective estrogen receptor modulator(s) (SERM(s), e.g., Lasofoxifene) and four or more pharmaceutically acceptable excipients. The pharmaceutical compositions may be able to form nanodroplets (e.g., by self-nanoemulsifying) in vaginal fluid and to deliver the one or more SERM(s) to the vagina of a female subject. The pharmaceutical compositions may be useful in treating or preventing vulvovaginal atrophy, dyspareunia, sexual dysfunction, osteoporosis, or breast cancer in a female subject.