Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones
摘要:
The present work demonstrates that the 1,3-diazetidifie-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and alpha -chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase. (C) 2001 Elsevier Science Ltd. All rights reserved.
Strengthened composite products and methods for making and using same
申请人:Georgia-Pacific Chemicals LLC
公开号:US10077217B2
公开(公告)日:2018-09-18
The disclosure provides strengthened products, including strengthened fibrous composite products and methods for making and using same and strengthened particulates, such as particulate fertilizer products, and methods for making and using same. The fibrous composite product can include a plurality of fibers and an at least partially cured strengthening resin. The fertilizer composition can include a particulate core that can include a plant nutrient, at least one coating layer of the strengthening resin, and at least one coating layer of a water insoluble material. The strengthening resin can include one or more aldehyde-based resins and one or more crosslinked resins. The crosslinked resin can include one or more polyamines at least partially crosslinked by one or more symmetric crosslinks and can include one or more azetidinium functional groups.
Resin compositions and methods for making and using same
申请人:ECOLAB USA INC.
公开号:US10144818B2
公开(公告)日:2018-12-04
Resins compositions and methods for making and using same. The resin composition can include a glyoxalated polyacrylamide resin and a polyamide-epihalohydrin resin. The polyamide-epihalohydrin resin can include a polyamine partially crosslinked with a bridging moiety and having azetidinium ions. The bridging moiety can be derived from a functionally symmetric crosslinker. A fiber product can include a plurality of fibers and the resin composition, where the resin composition can be at least partially cured.
Creping adhesives can include one or more crosslinked resins having the chemical formula (O), (P), or (Q), where RX can be a crosslinking moiety, each RY can independently be a substituted or unsubstituted organic diyl moiety, and each A− can independently be an anion. The creping adhesive can have a cylinder probe adhesion of about 100 gram-force to about 300 gram-force. The creping adhesive can have a peel adhesion of about 20 g/cm to about 110 g/cm.