(1R,5S)-6-methyl-3,6-diazabicyclo[3.2.0]heptane | 1419075-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂卓
• 英文名称: (1R,5S)-6-methyl-3,6-diazabicyclo[3.2.0]heptane
• CAS: 1419075-91-4
• 化学式: C₆H₁₂N₂
• 分子量: 112.17
• InChiKey: ACXCQTFLEBVHNU-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS<br/>[FR] BIS-PYRIDYLPYRIDONES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE L'HORMONE DE MÉLANO-CONCENTRATION
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2010141540A1

  公开（公告）日：2010-12-09

  The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1 ), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

  这项发明提供了新型的双吡啶基吡啶酮，它们是黑素浓集激素受体1（MCHR1）的拮抗剂，包含它们的药物组合物，它们的制备方法，以及它们在治疗和治疗肥胖和糖尿病中的用途。
• Macrocyclic Benzofused Pyrimidine Derivatives
  申请人：Altenbach Robert J.

  公开号：US20080188452A1

  公开（公告）日：2008-08-07

  Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

  本文描述了大环苯并嘧啶化合物、包含这种化合物的组合物、制备这种化合物的方法，以及使用这种化合物和组合物治疗和预防疾病、病症和障碍的方法。
• NOVEL SULFONAMIDEUREA COMPOUNDS
  申请人：Inflazome Limited

  公开号：US20220194923A1

  公开（公告）日：2022-06-23

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R 1 and R 3 are each independently hydrogen or an optionally substituted hydrocarbyl group, or R 1 and R 3 together with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and R 2 is a cyclic group substituted at the position, wherein R 2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
• US8735411B2
  申请人：——

  公开号：US8735411B2

  公开（公告）日：2014-05-27
• [EN] NOVEL SULFONAMIDEUREA COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SULFONAMIDE URÉE
  申请人：INFLAZOME LTD

  公开号：WO2020035464A1

  公开（公告）日：2020-02-20

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 and R3 are each independently hydrogen or an optionally substituted hydrocarbyl group, or R1 and R3 together with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and R2 is a cyclic group substituted at the oposition, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.