N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)but-2-yn-1-yl)methanesulfonamide | 1351647-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)but-2-yn-1-yl)methanesulfonamide
• 英文别名: N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)but-2-ynyl]methanesulfonamide
• CAS: 1351647-28-3
• 化学式: C₁₄H₁₈N₂O₂S
• 分子量: 278.37
• InChiKey: GRYHGBSZTSZMTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NONE-HYDROPHOBIC COMPOUNDS FOR USE IN TREATING METASTASIS AND/OR CARTILAGE DEFECT
  申请人：Friedrich-Alexander-Universität Erlangen-Nürnberg

  公开号：EP3103450A1

  公开（公告）日：2016-12-14

  The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.

  本发明涉及其化合物、同系物、立体异构体和化学修饰化合物，及其在预防和/或治疗肿瘤转移和/或软骨缺损中的用途，以及包含此类化合物的药物组合物。
• Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect
  申请人：Friedrich-Alexander-Universität Erlangen-Nürnberg

  公开号：US10828281B2

  公开（公告）日：2020-11-10

  The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.

  本发明涉及其化合物、同系物、立体异构体和化学修饰化合物，及其在预防和/或治疗肿瘤转移和/或软骨缺损中的用途，以及包含此类化合物的药物组合物。
• NON-HYDROPHOBIC COMPOUNDS FOR USE IN TREATING METASTASIS AND/OR CARTILAGE DEFECT
  申请人：Friedrich-Alexander-Universität Erlangen-Nürnberg

  公开号：US20180280356A1

  公开（公告）日：2018-10-04

  The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.