Spiro[cyclopropane-1,9'-xanthene] | 56087-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Spiro[cyclopropane-1,9'-xanthene]
• 英文别名: spiro[cyclopropane-1,9'-xanthene]
• CAS: 56087-51-5
• 化学式: C₁₅H₁₂O
• 分子量: 208.26
• InChiKey: SBLSJLKDPWPZLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Spiro[cyclopropane-1,9'-xanthene] 在 盐酸 、 aluminum (III) chloride 、 ammonium acetate 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 邻二甲苯 、 乙腈 为溶剂， 生成 5,5'-(spiro[cyclopropane-1,9'-xanthene]-2',6'-diyl)bis(2-((S)-pyrrolidin-2-yl)-1H-imidazole)
  参考文献：
  名称：

  Potent bisimidazole-based HCV NS5A inhibitors bearing annulated tricyclic motifs

  摘要：

  This Letter describes the synthesis and biological evaluation of a number of functionalized bisimidazoles bearing annulated tricyclic motifs as potent inhibitors of HCV NS5A protein. Compound 4h, which contains a substituted tricyclic 6-6-6 xanthene, demonstrated broad genotypic spectrum, compelling potency, and good oral bioavailability with dose-dependent drug exposure level in multiple animal species. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.056

文献信息

• Potent bisimidazole-based HCV NS5A inhibitors bearing annulated tricyclic motifs
  作者：Min Zhong、Eric Peng、Ningwu Huang、Qi Huang、Anja Huq、Meiyen Lau、Richard Colonno、Leping Li

  DOI：10.1016/j.bmcl.2014.10.056

  日期：2014.12

  This Letter describes the synthesis and biological evaluation of a number of functionalized bisimidazoles bearing annulated tricyclic motifs as potent inhibitors of HCV NS5A protein. Compound 4h, which contains a substituted tricyclic 6-6-6 xanthene, demonstrated broad genotypic spectrum, compelling potency, and good oral bioavailability with dose-dependent drug exposure level in multiple animal species. (C) 2014 Elsevier Ltd. All rights reserved.