(2R)-1-(1-benzofuran-2-yl)-2-hydroxypropan-1-one | 827322-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (2R)-1-(1-benzofuran-2-yl)-2-hydroxypropan-1-one
• CAS: 827322-66-7
• 化学式: C₁₁H₁₀O₃
• 分子量: 190.19
• InChiKey: MKSWKMJQMGRDGY-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2R)-1-(1-benzofuran-2-yl)-2-hydroxypropan-1-one 在 三溴化磷 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

  摘要：

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

  公开号：

  WO2024108179A2
• 作为产物：
  描述：

  苯并呋喃-2-羧酸 在 1-羟基苯并三唑 、 臭氧 、 2-(Phenylsulfonyl)-3-phenyloxaziridin 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 反应 20.25h， 生成 (2R)-1-(1-benzofuran-2-yl)-2-hydroxypropan-1-one
  参考文献：
  名称：

  2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

  摘要：

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

  公开号：

  WO2024108179A2

文献信息

• 2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT
  申请人：[en]TACTOGEN INC

  公开号：WO2024108179A2

  公开（公告）日：2024-05-23

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.