cis-Clomiphene Hydrochloride | 14158-66-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: cis-Clomiphene Hydrochloride
• 英文别名: 2-[4-[(Z)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine;hydrochloride
• CAS: 14158-66-8
• 化学式: C26H29Cl2NO
• mdl: MFCD08060098
• 分子量: 442.4
• InChiKey: KKBZGZWPJGOGJF-OQKDUQJOSA-N

物化性质

• 熔点：
  149-150.5 °C
• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Trans-Clomiphene Formulations and Uses Thereof
  申请人：REPROS THERAPEUTICS INC.

  公开号：US20150202167A1

  公开（公告）日：2015-07-23

  The present invention provides iraws-clomiphene and pharmaceutically acceptable salts and solvates thereof, characterized in that trans-clomiphene is in particulate form having a specific size range. The invention is also directed to pharmaceutical compositions comprising or formulated using trans-clomiphene or pharmaceutically acceptable salts and solvates having a specified size range and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.

  本发明提供了具有特定粒度范围的颗粒状反式克罗米芬和药学上可接受的盐和溶剂化物，该发明还涉及包含或制备使用具有特定粒度范围的反式克罗米芬或药学上可接受的盐和溶剂化物的药物组合物，并将其用于治疗包括继发性性腺功能减退症、2型糖尿病、高胆固醇、高甘油三酯、消耗症、脂肪萎缩症、女性和男性不孕症、良性前列腺增生、前列腺癌、乳腺癌、卵巢癌和子宫内膜癌等疾病。
• DOSING REGIMES FOR TRANS-CLOMIPHENE
  申请人：Podolski Joseph S.

  公开号：US20090215907A1

  公开（公告）日：2009-08-27

  The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism and disorders related thereto, including reduction of muscle mass, limitation of body performance capacity, reduction of bone density, reduction of libido, reduction of potency, reduction of benign prostatic hyperplasia and infertility.
• Trans-Clomiphene for Metabolic Syndrome
  申请人：van As Andrew

  公开号：US20120022167A1

  公开（公告）日：2012-01-26

  The present invention relates to the administration of compositions comprising an antiestrogen, preferably trans-clomiphene, for treating metabolic syndrome in a subject. The invention is also directed to methods for reducing fasting glucose levels in a subject by administering a composition comprising an antiestrogen, preferably trans-clomiphene.
• Methods and Materials for the Treatment of Testosterone Deficiency in Men
  申请人：REPROS THERAPEUTICS INC.

  公开号：US20150265553A1

  公开（公告）日：2015-09-24

  The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism.
• US7368480B2
  申请人：——

  公开号：US7368480B2

  公开（公告）日：2008-05-06