11-Fluoro-5-methyl-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene | 1415379-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 11-Fluoro-5-methyl-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene
• 英文别名: 11-fluoro-5-methyl-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene
• CAS: 1415379-63-3
• 化学式: C₁₁H₈FN₃
• 分子量: 201.2
• InChiKey: WFTJLPHLMVIGBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Imaging Agents for Detecting Neurological Dysfunction
  申请人：Szardenings Anna Katrin

  公开号：US20120302755A1

  公开（公告）日：2012-11-29

  Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

  本文公开了一种诊断哺乳动物阿尔茨海默病或其易感性的化合物和方法，其中该方法包括向哺乳动物施加诊断有效量的放射性标记化合物，所述化合物选自放射性标记的咔唑衍生物和其衍生物以及三唑衍生物组成的群体，允许该化合物分布到脑组织中，并成像脑组织，其中与正常控制结合水平相比，化合物对脑组织的结合增加表明哺乳动物正在患有或有发展阿尔茨海默病的风险。
• Imaging agents for detecting neurological dysfunction
  申请人：Eli Lilly and Company

  公开号：US20150030540A1

  公开（公告）日：2015-01-29

  Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

  本文中披露了在哺乳动物中诊断阿尔茨海默病或其易感性的化合物和方法，该方法包括向哺乳动物施用诊断有效量的放射性标记化合物，所述化合物选自放射性标记的咔唑衍生物和其衍生物以及三唑衍生物的群组，使化合物分布到脑组织中，并成像脑组织，其中化合物与脑组织的结合增加，与正常对照水平的结合相比，表明哺乳动物正在患有或有发展阿尔茨海默病的风险。
• US8932557B2
  申请人：——

  公开号：US8932557B2

  公开（公告）日：2015-01-13