| 69674-66-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• CAS: 69674-66-4
• 化学式: C17H15NNaO3
• 分子量: 304.29
• InChiKey: SOZGOLIIBOWMKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Oral solid pharmaceutical form with sequential action for the administering of drugs with ulcerogenic side effect
  申请人：LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A.

  公开号：EP0167958A2

  公开（公告）日：1986-01-15

  Oral solid pharmaceutical form with antiinflammatory and analgesic activity, with sequential action, with protective effect on the gastric and duodenal mucosa against the action of the active principles having ulcerogenic effect, contained in the same pharmaceutical form. Said pharmaceutical form is constituted by a tablet comprising: (a) a centre core containing an active principle provided with antiinflammatory and analgesic activity, with ulcerogenic side effects; (b) a layer coating of said core, containing a second active principle provided with protective action for said gastric and duodenal mucosa, which is immediately released.

  具有消炎和镇痛活性的口服固体药剂，具有连续作用，对胃和十二指肠粘膜具有保护作用，防止具有致溃疡作用的活性成分对胃和十二指肠粘膜的作用，包含在同一药剂中。 所述药剂由片剂构成，片剂包括：(a)中心芯，内含具有消炎和镇痛活性的活性成分，具有致溃疡副作用；(b)所述中心芯的包衣层，内含对所述胃和十二指肠粘膜具有保护作用的第二种活性成分，可立即释放。
• METHOD OF INCREASING EPITHELIAL PERMEABILITY USING NANOPARTICLES
  申请人：Carnegie Mellon University

  公开号：EP3651789A1

  公开（公告）日：2020-05-20
• EXTRACTS FOR THE REGENERATION OF LIGAMENTS
  申请人：University of Pittsburgh - of the Commonwealth System of Higher Education

  公开号：EP3755267A1

  公开（公告）日：2020-12-30
• Method of Increasing Epithelial Permeability Using Nanoparticles
  申请人：Carnegie Mellon University

  公开号：US20200129444A1

  公开（公告）日：2020-04-30

  Provided herein are devices and dosage forms useful in delivering macromolecular active ingredients or drugs, such as proteins, peptides and nucleic acids, through epithelial membranes, such as intestinal epithelium. Also provided are trans-epithelial drug delivery methods and methods of treatment of diabetes or insulin resistance, or to induce weight loss.
• Compositions and Methods for Modulating Permeability of Biological Barriers
  申请人：Carnegie Mellon University

  公开号：US20210113519A1

  公开（公告）日：2021-04-22

  A method of reversibly increasing intestinal epithelium permeability is provided. A plant polyphenol composition, such as a pelargonidin-containing composition is enterically-administered, e.g., with a high molecular weight therapeutic agent, such as insulin, such that therapeutic agents having high molecular weights can be delivered enterically. An oral dosage form for enteric delivery of high molecular weight therapeutic agents also is provided.