3-(α-Naphthoxy)-propansaeureamid | 16563-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(α-Naphthoxy)-propansaeureamid
• 英文别名: 3--propionsaeure-amid；3-Naphthalen-1-yloxypropanamide
• CAS: 16563-42-1
• 化学式: C₁₃H₁₃NO₂
• mdl: MFCD04275535
• 分子量: 215.252
• InChiKey: UPSHQQPTOMVDMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors
  申请人：——

  公开号：US20030134849A1

  公开（公告）日：2003-07-17

  A compound of formula (I) in which R 1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R 2 is amidated carboxy, R 3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor &agr; (TNF &agr;).

  式(I)的化合物，其中R1是卤素、低碳氧基、可选取代芳基、可选取代芳氧基、可选取代杂环基或可选取代低炔基，R2是酰胺化羧基，R3是氢或酰基，Ar是芳基或杂环基，X是硫代、亚砜基或磺酰基，Y和Z是各自的低碳链基，m和n分别是0到2的整数，以及其盐，用作基质金属蛋白酶（MMP）抑制剂或肿瘤坏死因子α（TNFα）的产生。
• [EN] THIAZEPINYL HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS<br/>[FR] DERIVES DE L'ACIDE THIAZEPINYLHYDROXAMIQUE EN TANT QU'INHIBITEURS DES METALLOPROTEINASES MATRICIELLES
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2001060808A1

  公开（公告）日：2001-08-23

  A compound of formula (I) in which R1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R2 is amidated carboxy, R3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor α (TNF α).

  化合物的化学式为（I），其中R1为卤素，较低的烷氧基，可选取代芳基，可选取代芳氧基，可选取代杂环基或可选取代较低的炔基，R2为酰胺化的羧基，R3为氢或酰基，Ar为芳基或杂环基，X为硫代基，亚砜基或磺酰基，Y和Z均为较低的烷基，m和n均为0到2的整数，以及其盐，用作基质金属蛋白酶（MMP）或肿瘤坏死因子α（TNFα）的抑制剂。
• Process for the production of alpha-halo-N,N-dimethylpropionamides
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0091677A1

  公开（公告）日：1983-10-19

  A process for the production of alpha-halo-N,N-dimethylpropionamides, preferably those which are optically active, comprising reacting the methyl or ethyl ester of an alpha-halopropionic acid with dimethylamine in an aqueous solution, with removal of the lower alkanol formed during the reaction.

  一种生产α-卤代-N,N-二甲基丙酰胺（最好是具有光学活性的α-卤代-N,N-二甲基丙酰胺）的工艺，包括在水溶液中将α-卤代丙酸的甲酯或乙酯与二甲胺反应，并除去反应过程中形成的低级烷醇。
• Solid polymeric dispersant composition for water-insoluble actives
  申请人：Narayanan S. Kolazi

  公开号：US20060039944A1

  公开（公告）日：2006-02-23

  A solid polymeric dispersant composition for water-insoluble actives includes a primary anionic polymer dispersing agent and a co-dispersant which is a vinyl lactam, in a defined weight ratio, and wettable powders, water dispersible granules and tablets thereof, for delivery of actives to a desired site.

  一种用于水不溶性活性物质的固体聚合物分散剂组合物，包括一种主阴离子聚合物分散剂和一种助分散剂（乙烯内酰胺），两者的重量比确定，以及可湿性粉剂、水分散粒剂和片剂，用于将活性物质输送到所需部位。
• THIAZEPINYL HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1259499A1

  公开（公告）日：2002-11-27