19-Ethyl-18-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,17-dione | 1260237-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 19-Ethyl-18-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,17-dione
• CAS: 1260237-36-2
• 化学式: C₂₀H₁₆N₂O₃
• 分子量: 332.359
• InChiKey: VQMPOZZDAMZOCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[7-[1-[tert-butyl(dimethyl)silyl]oxypropyl]-9-oxo-11H-indolizino[1,2-b]quinolin-8-yl]acetonitrile 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以29%的产率得到19-Ethyl-18-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,17-dione
  参考文献：
  名称：

  Synthesis of new cytotoxic E-ring modified camptothecins

  摘要：

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.130

文献信息

• Synthesis of new cytotoxic E-ring modified camptothecins
  作者：Salvatore Cananzi、Sabrina Dallavalle、Alberto Bargiotti、Lucio Merlini、Roberto Artali、Giovanni Luca Beretta

  DOI：10.1016/j.tetlet.2010.09.130

  日期：2010.12

  In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460. (C) 2010 Elsevier Ltd. All rights reserved.