Aurora kinase inhibitor as703569

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Aurora kinase inhibitor as703569
• 英文别名: 3-[[5-fluoro-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
• 化学式: C₂₄H₃₀FN₇O
• 分子量: 451.5
• InChiKey: KSOVGRCOLZZTPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  99.4
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Methods of Treating Cell Proliferative Disorders
  申请人：Hitoshi Yasumichi

  公开号：US20090012045A1

  公开（公告）日：2009-01-08

  The present disclosure provides methods for the treatment of cell proliferative disorders by administration of a RET kinase inhibitor. Cell proliferative disorders treatable by the methods include, thyroid tumors.

  本公开提供了一种通过给予RET激酶抑制剂治疗细胞增殖性疾病的方法。这些方法可用于治疗的细胞增殖性疾病包括甲状腺肿瘤。
• Kinase Inhibitors And Their Uses
  申请人：Ding Pingyu

  公开号：US20070142402A1

  公开（公告）日：2007-06-21

  The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity.

  本公开提供了抑制蛋白激酶的化合物，例如JAK、Axl或Syk激酶，包括该化合物的组合物以及使用该化合物抑制蛋白激酶并治疗和/或预防与不适当激酶活性相关的疾病的方法。
• Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
  申请人：Argade Ankush

  公开号：US20060167249A1

  公开（公告）日：2006-07-27

  The present invention provides stereoisomers and stereoisomeric mixtures of 3-aminocarbonyl-bicycloheptene-2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.

  本发明提供了具有抗增殖活性的3-氨基羰基-双环庚烯-2,4-嘧啶二胺化合物的立体异构体和立体异构混合物，以及包含该化合物的组合物和使用该化合物抑制细胞增殖和治疗增殖性疾病，如肿瘤性癌症的方法。
• Cycloalkyl substituted pyrimidinediamine compounds and their uses
  申请人：Li Hui

  公开号：US20060035891A1

  公开（公告）日：2006-02-16

  The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.

  本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包括该化合物的组合物以及使用该化合物抑制细胞增殖和治疗增殖性疾病，如肿瘤性癌症的方法。
• Stereoisomerically Enriched 3-Aminocarbonyl Bicycloheptene Pyrimidinediamine Compounds and their Uses
  申请人：Argade Ankush

  公开号：US20080051412A1

  公开（公告）日：2008-02-28

  The present invention provides stereoisomers and stereoisomeric mixtures of 3-aminocarbonyl-bicycloheptene-2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.

  本发明提供了具有抗增殖活性的3-氨基羰基-双环庚烯-2,4-嘧啶二胺化合物的立体异构体和立体异构体混合物，包括含有该化合物的组合物和使用该化合物抑制细胞增殖和治疗增殖性疾病，如肿瘤性癌症的方法。