(S)-3,3,3-trifluoro-2-hydroxy-2-(1-naphthyl)-N-((1'R,2'R,3'R,5'S)-isopinocampheyl)propionamide | 1058658-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-3,3,3-trifluoro-2-hydroxy-2-(1-naphthyl)-N-((1'R,2'R,3'R,5'S)-isopinocampheyl)propionamide
• CAS: 1058658-87-9
• 化学式: C₂₃H₂₆F₃NO₂
• 分子量: 405.46
• InChiKey: UWOGJQFLNKHDOS-UHPXKSGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.78
• 重原子数：
  29.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (S)-5-(1-naphthyl)-5-trifluoromethyl-[1,3]-dioxolane-2,4-dione 、 (1R,2R,3R,5S)-(-)-Isopinocampheylamine 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (S)-3,3,3-trifluoro-2-hydroxy-2-(1-naphthyl)-N-((1'R,2'R,3'R,5'S)-isopinocampheyl)propionamide
  参考文献：
  名称：

  (1-Naphthyl)(trifluoromethyl) O-Carboxy Anhydride as a Chiral Derivatizing Agent: Eclipsed Conformation Enforced by Hydrogen Bonding

  摘要：

  The preparation of the (1-naphthyl)(trifluoromethyl) O-carboxy-anhydride 1 and its use as a chiral derivatizing agent with several a-chiral primary amines are reported. The very large Delta delta(RS) values observed in H-1 NMR have been correlated with a marked preference of the corresponding alpha-hydroxy-am ides for the eclipsed conformation. In comparison, the related O-methylated amides are shown to adopt staggered conformations, which substantiates the critical role of intramolecular hydrogen bonding in maximizing the anisotropic effect.

  DOI：

  10.1021/ol801930m