(S)-1-benzyl-3-(naphthalen-2-ylmethyl)-piperazine-2,5-dione | 947684-71-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-1-benzyl-3-(naphthalen-2-ylmethyl)-piperazine-2,5-dione
• 英文别名: (3S)-1-benzyl-3-(naphthalen-2-ylmethyl)piperazine-2,5-dione
• CAS: 947684-71-1
• 化学式: C₂₂H₂₀N₂O₂
• 分子量: 344.413
• InChiKey: SKVBEGQTELVSAB-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS
  申请人：Helicon Therapeutics, Inc.

  公开号：EP1989188A1

  公开（公告）日：2008-11-12
• THERAPEUTIC PIPERAZINES
  申请人：Dart Neuroscience (Cayman) Ltd

  公开号：EP2643000A2

  公开（公告）日：2013-10-02
• [EN] THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS<br/>[FR] PIPERAZINES THERAPEUTIQUES UTILISÉES COMME INHIBITEURS DE LA PDE4
  申请人：HELICON THERAPEUTICS INC

  公开号：WO2007100852A1

  公开（公告）日：2007-09-07

  [EN] The invention includes a compound of formula I; wherein R₁, X, Z, n, and m have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function in animals.
  [FR] La présente invention concerne un composé de formule I : dans laquelle R₁, X, Z, n et m ont l'une quelconque des significations indiquées dans le présent document, ainsi que les sels de tels composés, des compositions comprenant de tels composés et des méthodes thérapeutiques qui comprennent l'administration de tels composés. Les composés selon l'invention sont des inhibiteurs de la fonction de PDE4 et sont utiles pour améliorer les fonctions cognitives chez l'animal.
• [EN] THERAPEUTIC PIPERAZINES<br/>[FR] PIPÉRAZINES THÉRAPEUTIQUES
  申请人：HELICON THERAPEUTICS INC

  公开号：WO2012040258A2

  公开（公告）日：2012-03-29

  The invention includes a compound of formula I... wherein R1, Y, A, n, R4 and Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function and/or treating cognitive disorders or impariment, traumatic and/or ischemic injuries of the central and peripheral nervous system and/or psychiatric disorders in animals, especially humans.