N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-6-chloro-3,4-dihydro-2H-1-benzopyran-8-carboxamide | 175422-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-6-chloro-3,4-dihydro-2H-1-benzopyran-8-carboxamide
• 英文别名: 6-chloro-N-[2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)ethyl]-3,4-dihydro-2H-chromene-8-carboxamide
• CAS: 175422-19-2
• 化学式: C₁₉H₂₅ClN₂O₂
• 分子量: 348.873
• InChiKey: LMVSRGYYBGNPGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Benzopyrancarboxamide derivatives, salt thereof, process for the preparation of same and use thereof
  申请人：SANWA KAGAKU KENKYUSHO CO., LTD.

  公开号：EP0691341A1

  公开（公告）日：1996-01-10

  There are disclosed a benzopyrancarboxamide derivative of the formula    wherein R¹ is hydrogen atom or a lower alkyl group; R² is hydrogen atom, a lower alkyl group, halogen atom, an amino radical or an acylamino group; R³ is hydrogen atom, a lower alkyl group, a lower alkoxy group or halogen atom; dotted line is a possible double bond; and n is an integer of 1 - 5, and a pharmacologically acceptable salt of the compound, a process for the preparation of the compound and salt as well as use thereof. The derivative and salt can be easily synthesized, show powerful agonisting action to 5-HT₄ receptor and has very low side effect to central nerve system.

  公开了一种式如下的苯并吡喃甲酰胺衍生物 其中，R¹为氢原子或低级烷基；R²为氢原子、低级烷基、卤素原子、氨基或酰氨基；R³为氢原子、低级烷基、低级烷氧基或卤素原子；虚线为可能的双键；n为1-5的整数、 及其药理学上可接受的盐、化合物和盐的制备工艺及其用途。 该衍生物和盐易于合成，对 5-HT₄ 受体有很强的激动作用，对中枢神经系统的副作用很小。