3,5-dihydroxy-2-methyl-4H-chromen-4-one | 14153-16-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,5-dihydroxy-2-methyl-4H-chromen-4-one
• 英文别名: 3,5-Dihydroxy-2-methyl-chromon；3,5-Dihydroxy-2-methyl-chromone；3,5-dihydroxy-2-methylchromen-4-one
• CAS: 14153-16-3
• 化学式: C₁₀H₈O₄
• 分子量: 192.171
• InChiKey: AHUXDLHAOVQXCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [DE] CHROMON-KOMPLEXE<br/>[EN] CHROMONE COMPLEXES<br/>[FR] COMPLEXES DE CHROMONE
  申请人：MERCK PATENT GMBH

  公开号：WO2005097772A1

  公开（公告）日：2005-10-20

  Die Erfindung betrifft Komplexe bestimmter Chromon-Derivate, Zubereitungen, die solche Derivate enthalten, entsprechende Verfahren zur Herstellung der Chromon-Derivate bzw. von diese enthaltenden Zubereitungen und deren Verwendung, insbesondere zur Pflege, Konservierung oder Verbesserung des allgemeinen Zustandes der Haut oder Haare.

  这项发明涉及特定的色酮衍生物复合物，含有这些衍生物的制剂，制备色酮衍生物或含有这些衍生物的制剂的相应方法以及它们的用途，特别是用于皮肤或头发的护理、保养或改善整体状态。
• ANTIBACTERIAL AGENT
  申请人：JUNTENDO EDUCATIONAL FOUNDATION

  公开号：US20150322033A1

  公开（公告）日：2015-11-12

  An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R 1 and R 4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R 2 and R 3 represents hydrogen atom or hydroxyl group; W represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R 1′ and R 5′ represents hydrogen atom; R 2′ and R 3′ represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R 4′ represents hydrogen atom or hydroxyl group).

  一种抗菌剂，包括以下一般式（I）所代表的化合物，该化合物可以对已经对喹诺酮产生抗药性的细菌表现出强效的抗菌活性（在该式中，R1和R4代表氢原子、羟基或较低的烷氧基；R2和R3代表氢原子或羟基；W代表氢原子、较低的环烷基或较低的烷氧基；R1'和R5'代表氢原子；R2'和R3'代表氢原子、羟基或较低的烷氧基；R4'代表氢原子或羟基）。
• TETRAPEPTIDE AND COMPOSITIONS COMPRISING TETRAPEPTIDES
  申请人：The Boots Company plc

  公开号：EP4000596A1

  公开（公告）日：2022-05-25

  According to the present invention, there is provided a tetrapeptide, capable of inducing dermal extracellular matrix protein upregulation, selected from the group consisting of tetrapeptides having the amino acid sequence U-LSXX-Z wherein L is used to denote amino acid Leucine and S is used to denote Serine, as per the internationally recognised single letter code for amino acids. X denotes an amino acid selected from the group consisting of Valine (V), Aspartic acid (D), Proline (P), Glycine (G) and mixtures thereof. At the N-terminal end, U is selected from the group consisting of H, -CO-R1, -SO2-R1 or a biotinyl group. At the C-terminal end, Z is selected from the group consisting of OH, O R1, NHR1 or NR1R2. R1 and R2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclical, polycyclic, unsaturated, hydroxylates, carbonylated, phosphorylated and/or sulphurous, said groups comprising from 1 to 24 carbon atoms and being capable of including one or more heteroatoms O, S and/or N.

  根据本发明，提供了一种能够诱导真皮细胞外基质蛋白上调的四肽，它选自具有 U-LSXX-Z 氨基酸序列的四肽组成的组，其中根据国际公认的氨基酸单字母代码，L 表示氨基酸亮氨酸，S 表示丝氨酸。X 表示选自缬氨酸 (V)、天冬氨酸 (D)、脯氨酸 (P)、甘氨酸 (G) 及其混合物的氨基酸。在 N 端，U 选自 H、-CO-R1、-SO2-R1 或生物素基团组成的组。在 C 端，Z 选自 OH、O R1、NHR1 或 NR1R2 所组成的组。R1 和 R2 独立地选自由烷基、芳基、芳烷基、烷芳基、烷氧基、糖基和芳氧基组成的组，这些基团可以是线性的、支链的、环状的、多环的、不饱和的、羟基化的、羰基化的、磷酸化的和/或硫磺化的，所述基团包括 1 至 24 个碳原子，并可包括一个或多个杂原子 O、S 和/或 N。
• Skin care composition
  申请人：THE BOOTS COMPANY PLC

  公开号：US10335357B2

  公开（公告）日：2019-07-02

  A water-in-oil emulsion comprising less than 60% water, and wherein said emulsion comprises an oil phase and a water phase, and wherein the water phase comprises a dipeptide selected from the group consisting of acetyl dipeptide (1) cetyl ester, acetyl dipeptide (3) aminohexanoate, azelaoyl bisdipeptide (10), coumaroyl dipeptide (3), dicetyl dipeptide (9), dipeptide diamino butyroyl benzylamide diacetate, dipeptide (1), dipeptide (10), dipeptide (11), dipeptide (12), dipeptide (15), dipeptide (16), dipeptide (17), dipeptide (18), dipeptide (19), dipeptide (2), dipeptide (20), dipeptide (3), dipeptide (4), dipeptide (5), dipeptide (6), dipeptide (7), dipeptide (8), dipeptide (8) HCL, dipeptide (9), hexanoyl dipeptide (3) norleucine acetate, methyl undecylenoyl dipeptide (16), nicotinoyl dipeptide (22), nicotinoyl dipeptide (23), nicotinoyl dipeptide (24), nicotinoyl dipeptide (26), oleoyl dipeptide (15), palmitoyl dipeptide (10), palmitoyl dipeptide (13), palmitoyl dipeptidel (7), palmitoyl dipeptide (5) diaminobutyroyl hydroxythreonine, palmitoyl dipeptide (5) diaminohydroxybutyrate, palmitoyl dipeptide (7) and mixtures thereof.

  一种油包水型乳液，含水量低于 60%，其中所述乳液包括油相和水相，水相包括选 自以下组别的二肽：乙酰基二肽(1)十六烷基酯、乙酰基二肽(3)氨基己酸酯、乙酰二肽(3)氨基己酸酯、偶氮甲酰二肽(10)、香豆酰二肽(3)、二乙酰基二肽(9)、二氨基丁酰基苄酰胺二乙酸酯、二肽(1)二肽 (10)，二肽 (11)，二肽 (12)，二肽 (15)，二肽 (16)，二肽 (17)，二肽 (18)，二肽 (19)，二肽 (2)、二肽 (20), 二肽 (3), 二肽 (4), 二肽 (5), 二肽 (6), 二肽 (7), 二肽 (8), 二肽 (8) HCL, 二肽 (9)、己酰二肽 (3) 醋酸诺亮氨酸、甲基十一碳烯酰基二肽 (16)、烟酰二肽 (22)、烟酰二肽 (23)、烟酰二肽 (24)烟酰二肽 (26)、油酰二肽 (15)、棕榈酰二肽 (10)、棕榈酰二肽 (13)、棕榈酰二肽 (7)、棕榈酰二肽 (5) 二氨基丁酰羟基苏氨酸、棕榈酰二肽 (5) 二氨基羟基丁酸酯、棕榈酰二肽 (7) 及其混合物。
• CHROMON-KOMPLEXE
  申请人：Merck Patent GmbH

  公开号：EP1732913A1

  公开（公告）日：2006-12-20