(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-4-carboxylic acid | 23978-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-4-carboxylic acid
• CAS: 23978-84-9
• 化学式: C₂₂H₃₀O₄
• 分子量: 358.5
• InChiKey: VITZNDKHSIWPSR-HZPDHXFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR PURIFICATION OF CANNABINOIC ACIDS FROM PLANT MATERIAL EXTRACT<br/>[FR] PROCÉDÉ DE PURIFICATION D'ACIDES CANNABINOÏDES À PARTIR D'UN EXTRAIT DE MATÉRIEL VÉGÉTAL
  申请人：AL&AM PHARMACHEM LTD

  公开号：WO2020016875A1

  公开（公告）日：2020-01-23

  The present invention relates to a highly economic process for the purification of a cannabinoid acid, more specifically THCA or CBDA, from either a crude cannabis plant material or a cell culture of said cannabis plant, using ion exchange resins. The purified cannabinoid acid obtained may then be decarboxylated to yield the corresponding cannabinoid, i.e., THC or CBD, respectively.

  本发明涉及一种高效经济的过程，用于从粗制大麻植物材料或所述大麻植物的细胞培养物中纯化大麻酸类物质，更具体地说是THCA或CBDA，使用离子交换树脂。然后可以将获得的纯化大麻酸类物质脱羧，得到相应的大麻素，即THC或CBD。
• Cannabinoid composition and products including α-tocopherol
  申请人：Constance Therapeutics, Inc.

  公开号：US10238745B2

  公开（公告）日：2019-03-26

  A cannabinoid composition having an excipient including α-tocopherol and at least one isolated cannabinoid having a purity of greater than 80%. The α-tocopherol inhibits oxidation, regulates viscosity of the composition, and improves bioavailability of the cannabinoid. The composition includes a carrier oil mixed with the excipient and cannabinoid. In one embodiment, the at least one cannabinoid is an isolated cannabinoid having a greater than 80% purity, and preferably greater than 90% purity. The at least one cannabinoid is selected from the group consisting of phytocannabinoids, endocannabinoids, synthetic cannabinoids, and combinations thereof. The cannabinoid may be derived from plants other than cannabis sativa, or synthesized from fungi, bacteria, yeast or other synthetic method. Preferably the α-tocopherol comprises at least 10% w/w of the composition.

  一种大麻素组合物，其赋形剂包括α-生育酚和至少一种纯度大于 80% 的分离大麻素。α-生育酚可抑制氧化，调节组合物的粘度，提高大麻素的生物利用度。组合物包括与赋形剂和大麻素混合的载体油。在一个实施方案中，至少一种大麻素是分离出来的大麻素，纯度大于 80%，最好大于 90%。至少一种大麻素选自植物大麻素、内源性大麻素、合成大麻素及其组合组成的组。大麻素可以从大麻以外的植物中提取，也可以从真菌、细菌、酵母或其他合成方法中合成。α-生育酚最好至少占组合物重量的 10%。
• Breeding, production, processing and use of medical cannabis
  申请人：BIOTECH INSTITUTE, LLC

  公开号：US10441617B2

  公开（公告）日：2019-10-15

  The invention provides compositions and methods for the breeding, production, processing and use of medical cannabis.

  本发明提供了用于培育、生产、加工和使用医用大麻的组合物和方法。
• Bioactive concentrates and uses thereof
  申请人：SC LABORATORIES, INC.

  公开号：US10792318B2

  公开（公告）日：2020-10-06

  The present invention relates to concentrates obtained from extraction from Cannabis, preferably cannabinoid and/or terpene concentrates, and formulation of the concentrates, particularly for use for direct vaporization, infusion into edible matrices, in electronic inhalation devices, and as nutraceuticals.

  本发明涉及从大麻中提取的浓缩物，最好是大麻素和/或萜类浓缩物，以及浓缩物的配方，特别是用于直接汽化、注入可食用基质、电子吸入装置和作为营养保健品。
• Cannabis oil compositions and methods for preparation thereof
  申请人：Constance Therapeutics, Inc.

  公开号：US10806707B2

  公开（公告）日：2020-10-20

  The present invention provides cannabis oil compositions, including cannabis oil compositions containing vitamin E, and methods for preparing the cannabis oil compositions. In some embodiments, the invention provides a method for preparing a cannabis oil composition comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate; filtering the eluate with a filter to produce a filtrate; evaporating the solvent from the filtrate with a distiller to produce a distillate; and purging the distillate under conditions sufficient to remove residual solvent. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract. Blended cannabis oil compositions containing mixtures of cannabis oil preparations are also described.

  本发明提供了大麻油组合物，包括含有维生素 E 的大麻油组合物，以及制备大 麻油组合物的方法。在一些实施例中，本发明提供了一种制备大麻油组合物的方法，包括用溶剂从大麻植物材料中洗脱大麻素以产生洗脱液；用过滤器过滤洗脱液以产生滤液；用蒸馏器蒸发滤液中的溶剂以产生蒸馏物；以及在足以去除残留溶剂的条件下净化蒸馏物。在某些实施方案中，该方法还包括将一定量的维生素 E 与萃取物混合。还描述了含有大麻油制剂混合物的混合大麻油组合物。