(E/Z)-4,4'-Dihydroxy Tamoxifen | 70822-67-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E/Z)-4,4'-Dihydroxy Tamoxifen
• 英文别名: 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)but-1-en-2-yl]phenol
• CAS: 70822-67-2
• 化学式: C₂₆H₂₉NO₃
• 分子量: 403.5
• InChiKey: IDGYIEFKHBMNKS-QPLCGJKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE
  申请人：ShanghaiTech University

  公开号：EP3778590A1

  公开（公告）日：2021-02-17

  The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

  本公开涉及式（I）化合物及其抗肿瘤用途，以及它们的式（III）中间体、式（IV）中间体及其用途。式（I）化合物对特定靶蛋白具有降解作用，主要由三部分组成。第一部分是能与蛋白质结合的小分子化合物（SMBP，Small Molecules Binding Protein），第二部分 LIN 是连接体，三部分 ULM 是泛素配体（ULM，Ubiquitin Ligase Binding Moiety），其中 SMBP 与 LIN 共价结合，LIN 与 ULM 共价结合。本公开中设计和合成的一系列化合物具有广泛的药理活性，包括降解特定蛋白质和/或抑制特定蛋白质活性的功能，因此可用于相关的肿瘤治疗。
• [EN] PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE<br/>[FR] COMPOSÉ CIBLANT UNE DÉGRADATION PROTÉIQUE, UTILISATION ANTITUMORALE, INTERMÉDIAIRE DE CELUI-CI ET UTILISATION DE L'INTERMÉDIAIRE<br/>[ZH] 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
  申请人：UNIV SHANGHAI TECH

  公开号：WO2019196812A1

  公开（公告）日：2019-10-17

  本公开涉及式(I)化合物及其抗肿瘤应用，和其中间体式(III)化合物、式(IV)化合物及其应用。式(I)化合物对特定靶蛋白具有降解作用，其主要由三部分组成，第一部分能够结合蛋白的小分子化合物(SMBP，Small Molecules Binding Protein)；第二部分LIN是链接单元(Linker)；第三部分ULM是具有泛素化功能的配体(ULM,Ubiquitin Ligase BindingMoiety)；其中SMBP和LIN共价结合，且LIN与ULM共价结合。本公开设计合成的一系列化合物具有广泛的药理活性，有降解特定蛋白和/或抑制活性的功能，可用于相关的肿瘤治疗。
• 1,1,2-TRIARYL-1-BUTENE DERIVATIVES
  申请人：TAIHO PHARMACEUTICAL COMPANY LIMITED

  公开号：EP0272330B1

  公开（公告）日：1991-05-22
• TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES
  申请人：ShanghaiTech University

  公开号：US20220117982A1

  公开（公告）日：2022-04-21

  The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.
• US4897503A
  申请人：——

  公开号：US4897503A

  公开（公告）日：1990-01-30