N,N-dimethyl-3-((4-phenylpiperazin-1-yl)methyl)aniline | 1233355-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N,N-dimethyl-3-((4-phenylpiperazin-1-yl)methyl)aniline
• 英文别名: N,N-dimethyl-3-[(4-phenylpiperazin-1-yl)methyl]aniline
• CAS: 1233355-07-1
• 化学式: C₁₉H₂₅N₃
• 分子量: 295.428
• InChiKey: LEMJIFBBYVAIRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 、 (5aR,6R,9S,9aS)-3-((3-(dimethylamino)benzyl)oxy)-1,5,5a,6,9,9a-hexahydro-6,9-methanobenzo[e][1,3,2]dioxaphosphepine 3-oxide 在 Grubbs catalyst first generation 、 四丁基碘化铵 、 potassium carbonate 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 生成 N,N-dimethyl-3-((4-phenylpiperazin-1-yl)methyl)aniline
  参考文献：
  名称：

  ROMP-Derived Oligomeric Phosphates for Application in Facile Benzylation

  摘要：

  The development of new ROMP-based oligomeric benzyl phosphates (OBPn) is reported for use as soluble, stable benzylating reagents. These oligomeric reagents are readily synthesized from commercially available materials and conveniently polymerized and purified in a one-pot process, affording bench-stable, pure white, free-flowing solids on multigram scale. Utilization in benzylation reactions with a variety of nucleophiles is reported.

  DOI：

  10.1021/ol1006604

文献信息

• US9029457B2
  申请人：——

  公开号：US9029457B2

  公开（公告）日：2015-05-12
• ROMP-Derived Oligomeric Phosphates for Application in Facile Benzylation
  作者：Toby R. Long、Pradip K. Maity、Thiwanka B. Samarakoon、Paul R. Hanson

  DOI：10.1021/ol1006604

  日期：2010.7.2

  The development of new ROMP-based oligomeric benzyl phosphates (OBPn) is reported for use as soluble, stable benzylating reagents. These oligomeric reagents are readily synthesized from commercially available materials and conveniently polymerized and purified in a one-pot process, affording bench-stable, pure white, free-flowing solids on multigram scale. Utilization in benzylation reactions with a variety of nucleophiles is reported.