butyl-hexyl tin oxide | 1428738-15-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 英文名称: butyl-hexyl tin oxide
• 英文别名: Butyl-hexyl-oxotin
• CAS: 1428738-15-1
• 化学式: C₁₀H₂₂OSn
• 分子量: 276.994
• InChiKey: KRIMHYXNSWSJBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.79
• 重原子数：
  12.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-氯-N-羟基苯甲酰胺 、 butyl-hexyl tin oxide 以 乙醇 、 甲苯 为溶剂， 反应 6.0h， 以45%的产率得到[(nBu)(nHex)Sn{4-chloro-N-hydroxybenzamide}2]
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity of novel mixed-ligand butyl-hexyltin(IV) complexes with N-hydroxybenzamides

  摘要：

  Five new mononuclear butyl-hexyltin(IV) complexes with para-position substituents of N-hydroxybenzamide anions [para-position substituent = H (1), F (2), Cl (3), Br (4), 1(5)], formulated as the [(n)Bu(n)Hex-SnL2] (Bu = butyl, Hex = hexyl, HL = substituted N-hydroxybenzamide), were prepared and characterized by elemental analyses, FT-IR, H-1, C-13, Sn-119 NMR spectroscopies. Crystal structure of complex 2 was determined by X-ray diffraction analysis. The cytotoxicity was tested by SRB assay. The results indicate that the complex 5 with iodine atoms has the best cytotoxicity against KB cells, even being better than that of cisplatin. It suggests that both halogens and alkyl groups around tin have important effects on cytotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.08.055
• 作为产物：
  描述：

  butyldichloro(hexyl)stannane 、 水 在 氨 作用下， 以85%的产率得到butyl-hexyl tin oxide
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity of novel mixed-ligand butyl-hexyltin(IV) complexes with N-hydroxybenzamides

  摘要：

  Five new mononuclear butyl-hexyltin(IV) complexes with para-position substituents of N-hydroxybenzamide anions [para-position substituent = H (1), F (2), Cl (3), Br (4), 1(5)], formulated as the [(n)Bu(n)Hex-SnL2] (Bu = butyl, Hex = hexyl, HL = substituted N-hydroxybenzamide), were prepared and characterized by elemental analyses, FT-IR, H-1, C-13, Sn-119 NMR spectroscopies. Crystal structure of complex 2 was determined by X-ray diffraction analysis. The cytotoxicity was tested by SRB assay. The results indicate that the complex 5 with iodine atoms has the best cytotoxicity against KB cells, even being better than that of cisplatin. It suggests that both halogens and alkyl groups around tin have important effects on cytotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.08.055